Designing hydrogels as vitreous substitutes in ophthalmic surgery

K. E. Swindle-Reilly, N. Ravi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


In this chapter, the optimization of the design of vitreous substitutes will be discussed. First, a review will explain the structure and function of the vitreous humor and the need for a better vitreous substitute. The approach taken in this work will be to develop a biomimetic vitreous substitute. As a result, the next section will discuss the biomechanics of the natural vitreous humor and the development of an animal model for the ideal vitreous substitute. Mixture design is used to screen candidates rapidly for use as in situ-forming polymeric hydrogel vitreous substitutes. Statistical experimental design is used to determine the effects of the crosslinker content, hydrophobic substitution, and polymer concentration in the hydrogel on the optomechanical properties. In addition, the equilibrium swelling properties are characterized and the osmotic pressure exerted by the hydrogel is calculated to determine whether or not these hydrogels could tamponade the retina via exertion of a slight osmotic pressure as vitreous substitutes. 2010 Woodhead Publishing Limited All rights reserved.

Original languageEnglish
Title of host publicationBiomaterials and Regenerative Medicine in Ophthalmology
PublisherElsevier Inc.
Number of pages35
ISBN (Print)9781845694432
StatePublished - Dec 2009


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