Design, synthesis, and preclinical characterization of the selective androgen receptor modulator (SARM) RAD140

Chris P. Miller, Maysoun Shomali, C. Richard Lyttle, Louis St L. O'dea, Hillary Herendeen, Kyla Gallacher, Dottie Paquin, Dennis R. Compton, Bishwabhusan Sahoo, Sean A. Kerrigan, Matthew S. Burge, Michael Nickels, Jennifer L. Green, John A. Katzenellenbogen, Alexei Tchesnokov, Gary Hattersley

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalACS Medicinal Chemistry Letters
Volume2
Issue number2
DOIs
StatePublished - Feb 10 2011

Keywords

  • Androgen
  • Herschberger assay
  • SARM
  • cachexia
  • oxadiazole
  • primate

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