Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

John Stephen Taylor

doi:10.1016/j.dnarep.2015.09.025

Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

John Stephen Taylor

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.

Original language	English
Pages (from-to)	59-67
Number of pages	9
Journal	DNA Repair
Volume	36
DOIs	https://doi.org/10.1016/j.dnarep.2015.09.025
State	Published - 2015

Keywords

AP sites
Chromatin
Dinucleosome
DNA damage
DNA photoproducts
DNA repair
Histones
Linker
Nucleosome
Photocaged
Solid phase DNA synthesis

Access to Document

10.1016/j.dnarep.2015.09.025

Cite this

@article{245516d786da4aaab5857d49dd695a92,

title = "Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage",

abstract = "How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.",

keywords = "AP sites, Chromatin, Dinucleosome, DNA damage, DNA photoproducts, DNA repair, Histones, Linker, Nucleosome, Photocaged, Solid phase DNA synthesis",

author = "Taylor, {John Stephen}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

doi = "10.1016/j.dnarep.2015.09.025",

language = "English",

volume = "36",

pages = "59--67",

journal = "DNA Repair",

issn = "1568-7864",

}

TY - JOUR

T1 - Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

AU - Taylor, John Stephen

PY - 2015

Y1 - 2015

N2 - How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.

AB - How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.

KW - AP sites

KW - Chromatin

KW - Dinucleosome

KW - DNA damage

KW - DNA photoproducts

KW - DNA repair

KW - Histones

KW - Linker

KW - Nucleosome

KW - Photocaged

KW - Solid phase DNA synthesis

UR - http://www.scopus.com/inward/record.url?scp=84961982145&partnerID=8YFLogxK

U2 - 10.1016/j.dnarep.2015.09.025

DO - 10.1016/j.dnarep.2015.09.025

M3 - Article

C2 - 26493358

AN - SCOPUS:84961982145

SN - 1568-7864

VL - 36

SP - 59

EP - 67

JO - DNA Repair

JF - DNA Repair

ER -

Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this