Design of a multicenter, double-blind study to assess the effects of prophylactic diltiazem on early reinfarction after non-Q-wave acute myocardial infarction: Diltiazem reinfarction study

Craig M. Pratt, Robert Gibson, William Boden, Pierre Theroux, Hans Strauss, Mihai Gheorghiade, Robert Capone, Michael Crawford, Robert Schlant, Daniel Arensberg, Robert Kleiger, M. Benjamin Perryman, Kenneth Schechtman, Phillip Young, Robert Roberts

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This protocol describes the design of an international study to examine the potential prophylactic effect of 14 days of diltiazem therapy to prevent early reinfarction in patients initially presenting with non-Q-wave acute myocardial infarction. Reinfarction was defined by the detection of a secondary elevation of plasma MB-creatine kinase. The results of clinical trials, instrumental in this protocol design, that established the increased propensity for early reinfarction after initial non-Q-wave infarction are described and the implications of the present study are discussed.

Original languageEnglish
Pages (from-to)906-910
Number of pages5
JournalThe American journal of cardiology
Volume58
Issue number10
DOIs
StatePublished - Nov 1 1986
Externally publishedYes

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