Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes

Debkalpa Goswami, Daniel A. Domingo-Lopez, Niamh A. Ward, Jeffrey R. Millman, Garry P. Duffy, Eimear B. Dolan, Ellen T. Roche

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long-term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroencapsulation device, where islets are incorporated into a selectively permeable membrane that can protect the transplanted cells from acute host response, whilst enabling delivery of insulin. These macroencapsulation systems have to meet a number of stringent and challenging design criteria in order to achieve the ultimate goal of reversing T1D. In this progress report, the design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets (SC-islets), highlighting distinct design parameters. Additionally, a perspective on the future for macroencapsulation systems is given, and how incorporating continuous sensing and closed-loop feedback can be transformative in advancing toward an autonomous biohybrid artificial pancreas.

Original languageEnglish
Article number2100820
JournalAdvanced Science
Volume8
Issue number16
DOIs
StatePublished - Aug 18 2021

Keywords

  • implantable therapeutic devices
  • macroencapsulation devices
  • stem cell derived islets
  • type 1 diabetes

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