@article{479fa1493176488485ae898b5019105e,
title = "Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes",
abstract = "Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long-term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroencapsulation device, where islets are incorporated into a selectively permeable membrane that can protect the transplanted cells from acute host response, whilst enabling delivery of insulin. These macroencapsulation systems have to meet a number of stringent and challenging design criteria in order to achieve the ultimate goal of reversing T1D. In this progress report, the design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets (SC-islets), highlighting distinct design parameters. Additionally, a perspective on the future for macroencapsulation systems is given, and how incorporating continuous sensing and closed-loop feedback can be transformative in advancing toward an autonomous biohybrid artificial pancreas.",
keywords = "implantable therapeutic devices, macroencapsulation devices, stem cell derived islets, type 1 diabetes",
author = "Debkalpa Goswami and Domingo-Lopez, {Daniel A.} and Ward, {Niamh A.} and Millman, {Jeffrey R.} and Duffy, {Garry P.} and Dolan, {Eimear B.} and Roche, {Ellen T.}",
note = "Funding Information: D.G., D.A.D.‐L., and N.A.W. contributed equally and are co‐first authors. G.P.D., E.B.D., and E.T.R. contributed equally and are co‐senior authors. E.T.R., E.B.D., and J.R.M. acknowledge a Pilot and Feasibility Grant from the Juvenile Diabetes Research Fund (1‐PNF‐2019‐778‐S‐B). J.R.M. was supported by the NIH (R01DK114233, R01DK127497), JDRF (5‐CDA‐2017‐391‐A‐N, 2‐PAR‐2020‐979‐S‐B), and Washington University School of Medicine (Departments of Medicine, Surgery, and Pediatrics). E.B.D. and N.A.W. acknowledge funding from the Science Foundation Ireland Royal Society University Research Fellowship (URF∖R1∖191335). G.P.D., E.B.D., and D.A.D.‐L. acknowledge the DELIVER project that received funding from the European Union's Horizon 2020 Marie Sk{\l}odowska‐Curie Actions programme under grant agreement number 812865. G.P.D. acknowledges funding from Science Foundation Ireland under grant SFI/12/RC/2278, Advanced Materials and Bioengineering Research (AMBER) Centre and financial support from the College of Medicine, Nursing and Health Sciences, National University of Ireland Galway. Schematics in Figure 3A were created with BioRender.com. Funding Information: D.G., D.A.D.-L., and N.A.W. contributed equally and are co-first authors. G.P.D., E.B.D., and E.T.R. contributed equally and are co-senior authors. E.T.R., E.B.D., and J.R.M. acknowledge a Pilot and Feasibility Grant from the Juvenile Diabetes Research Fund (1-PNF-2019-778-S-B). J.R.M. was supported by the NIH (R01DK114233, R01DK127497), JDRF (5-CDA-2017-391-A-N, 2-PAR-2020-979-S-B), and Washington University School of Medicine (Departments of Medicine, Surgery, and Pediatrics). E.B.D. and N.A.W. acknowledge funding from the Science Foundation Ireland Royal Society University Research Fellowship (URF?R1?191335). G.P.D., E.B.D., and D.A.D.-L. acknowledge the DELIVER project that received funding from the European Union's Horizon 2020 Marie Sk?odowska-Curie Actions programme under grant agreement number 812865. G.P.D. acknowledges funding from Science Foundation Ireland under grant SFI/12/RC/2278, Advanced Materials and Bioengineering Research (AMBER) Centre and financial support from the College of Medicine, Nursing and Health Sciences, National University of Ireland Galway. Schematics in Figure?3A were created with BioRender.com. Publisher Copyright: {\textcopyright} 2021 The Authors. Advanced Science published by Wiley-VCH GmbH",
year = "2021",
month = aug,
day = "18",
doi = "10.1002/advs.202100820",
language = "English",
volume = "8",
journal = "Advanced Science",
issn = "2198-3844",
number = "16",
}