Abstract
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
Original language | English |
---|---|
Pages (from-to) | 1167-1170 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 9 |
Issue number | 8 |
DOIs | |
State | Published - Apr 19 1999 |