Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter, D. J. Rogier, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Yan Zhang, John J. Talley

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

Original languageEnglish
Pages (from-to)1167-1170
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number8
DOIs
StatePublished - Apr 19 1999

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