Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter; D. J. Rogier; Matthew J. Graneto; Karen Seibert; Carol M. Koboldt; Yan Zhang; John J. Talley

doi:10.1016/S0960-894X(99)00158-4

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter, D. J. Rogier, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Yan Zhang, John J. Talley

Department of Anesthesiology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

Original language	English
Pages (from-to)	1167-1170
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(99)00158-4
State	Published - Apr 19 1999

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title = "Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors",

abstract = "A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.",

author = "Carter, {Jeffery S.} and Rogier, {D. J.} and Graneto, {Matthew J.} and Karen Seibert and Koboldt, {Carol M.} and Yan Zhang and Talley, {John J.}",

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T1 - Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

AU - Carter, Jeffery S.

AU - Rogier, D. J.

AU - Graneto, Matthew J.

AU - Seibert, Karen

AU - Koboldt, Carol M.

AU - Zhang, Yan

AU - Talley, John J.

PY - 1999/4/19

Y1 - 1999/4/19

N2 - A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

AB - A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

UR - http://www.scopus.com/inward/record.url?scp=0033583468&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(99)00158-4

DO - 10.1016/S0960-894X(99)00158-4

M3 - Article

C2 - 10328306

AN - SCOPUS:0033583468

SN - 0960-894X

VL - 9

SP - 1167

EP - 1170

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Abstract

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