Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter; D. J. Rogier; Matthew J. Graneto; Karen Seibert; Carol M. Koboldt; Yan Zhang; John J. Talley

doi:10.1016/S0960-894X(99)00158-4

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter, D. J. Rogier, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Yan Zhang, John J. Talley

Department of Anesthesiology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

Original language	English
Pages (from-to)	1167-1170
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(99)00158-4
State	Published - Apr 19 1999

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title = "Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors",

abstract = "A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.",

author = "Carter, {Jeffery S.} and Rogier, {D. J.} and Graneto, {Matthew J.} and Karen Seibert and Koboldt, {Carol M.} and Yan Zhang and Talley, {John J.}",

year = "1999",

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day = "19",

doi = "10.1016/S0960-894X(99)00158-4",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors. / Carter, Jeffery S.; Rogier, D. J.; Graneto, Matthew J.; Seibert, Karen; Koboldt, Carol M.; Zhang, Yan; Talley, John J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 8, 19.04.1999, p. 1167-1170.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

AU - Carter, Jeffery S.

AU - Rogier, D. J.

AU - Graneto, Matthew J.

AU - Seibert, Karen

AU - Koboldt, Carol M.

AU - Zhang, Yan

AU - Talley, John J.

PY - 1999/4/19

Y1 - 1999/4/19

N2 - A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

AB - A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

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U2 - 10.1016/S0960-894X(99)00158-4

DO - 10.1016/S0960-894X(99)00158-4

M3 - Article

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AN - SCOPUS:0033583468

VL - 9

SP - 1167

EP - 1170

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 8

ER -

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

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