Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter; D. J. Rogier; Matthew J. Graneto; Karen Seibert; Carol M. Koboldt; Yan Zhang; John J. Talley

doi:10.1016/S0960-894X(99)00158-4

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter, D. J. Rogier, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Yan Zhang, John J. Talley

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

Original language	English
Pages (from-to)	1167-1170
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(99)00158-4
State	Published - Apr 19 1999

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Carter, J. S., Rogier, D. J., Graneto, M. J., Seibert, K., Koboldt, C. M., Zhang, Y., & Talley, J. J. (1999). Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors. Bioorganic and Medicinal Chemistry Letters, 9(8), 1167-1170. https://doi.org/10.1016/S0960-894X(99)00158-4

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abstract = "A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.",

author = "Carter, {Jeffery S.} and Rogier, {D. J.} and Graneto, {Matthew J.} and Karen Seibert and Koboldt, {Carol M.} and Yan Zhang and Talley, {John J.}",

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AU - Carter, Jeffery S.

AU - Rogier, D. J.

AU - Graneto, Matthew J.

AU - Seibert, Karen

AU - Koboldt, Carol M.

AU - Zhang, Yan

AU - Talley, John J.

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AB - A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.

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JO - Bioorganic and Medicinal Chemistry Letters

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SN - 0960-894X

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