Design and synthesis of amidino-tyrosine derivatives as non-peptide fibrinogen receptor antagonists

Tian Lin Xu; Xun Tian Jiang; Wei Yi Hua; Pei Zhou Ni; Yong Mei Pei

doi:10.1016/S0960-894X(99)00308-X

Design and synthesis of amidino-tyrosine derivatives as non-peptide fibrinogen receptor antagonists

Tian Lin Xu, Xun Tian Jiang, Wei Yi Hua, Pei Zhou Ni, Yong Mei Pei

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The design, synthesis and antiaggregation activity of amidino-tyrosine derivatives based on Arg-Gly-Asp (RGD) tripepride sequence as non-peptide fibrinogen receptor antagonists is described. Optimization of the spacer and the substituent at the C-terminal is reported.

Original language	English
Pages (from-to)	1933-1936
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(99)00308-X
State	Published - Jul 19 1999

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title = "Design and synthesis of amidino-tyrosine derivatives as non-peptide fibrinogen receptor antagonists",

abstract = "The design, synthesis and antiaggregation activity of amidino-tyrosine derivatives based on Arg-Gly-Asp (RGD) tripepride sequence as non-peptide fibrinogen receptor antagonists is described. Optimization of the spacer and the substituent at the C-terminal is reported.",

author = "Xu, {Tian Lin} and Jiang, {Xun Tian} and Hua, {Wei Yi} and Ni, {Pei Zhou} and Pei, {Yong Mei}",

year = "1999",

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T1 - Design and synthesis of amidino-tyrosine derivatives as non-peptide fibrinogen receptor antagonists

AU - Xu, Tian Lin

AU - Jiang, Xun Tian

AU - Hua, Wei Yi

AU - Ni, Pei Zhou

AU - Pei, Yong Mei

PY - 1999/7/19

Y1 - 1999/7/19

N2 - The design, synthesis and antiaggregation activity of amidino-tyrosine derivatives based on Arg-Gly-Asp (RGD) tripepride sequence as non-peptide fibrinogen receptor antagonists is described. Optimization of the spacer and the substituent at the C-terminal is reported.

AB - The design, synthesis and antiaggregation activity of amidino-tyrosine derivatives based on Arg-Gly-Asp (RGD) tripepride sequence as non-peptide fibrinogen receptor antagonists is described. Optimization of the spacer and the substituent at the C-terminal is reported.

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U2 - 10.1016/S0960-894X(99)00308-X

DO - 10.1016/S0960-894X(99)00308-X

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AN - SCOPUS:0033584184

SN - 0960-894X

VL - 9

SP - 1933

EP - 1936

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Design and synthesis of amidino-tyrosine derivatives as non-peptide fibrinogen receptor antagonists

Abstract

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