Design and Analysis Considerations for a Sequentially Randomized HIV Prevention Trial

David Benkeser; Keith Horvath; Cathy J. Reback; Joshua Rusow; Michael Hudgens

doi:10.1007/s12561-020-09274-3

Design and Analysis Considerations for a Sequentially Randomized HIV Prevention Trial

David Benkeser
, Keith Horvath
, Cathy J. Reback
, Joshua Rusow
, Michael Hudgens

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The TechStep study is an ongoing randomized controlled trial in HIV-negative transgender youths and young adults, which will evaluate the efficacy of mobile health interventions for reducing risk behaviors. Several mobile interventions are available, which complicates the design. To evaluate different combinations of mHealth interventions, TechStep is utilizing a sequentially randomized design. In this work, we discuss the motivation for this design, propose robust methodology for the analysis of the trial, and evaluate the methodology via simulation.

Original language	English
Pages (from-to)	446-467
Number of pages	22
Journal	Statistics in Biosciences
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/s12561-020-09274-3
State	Published - Dec 1 2020

Keywords

HIV prevention
MHealth
Randomized trial
SMART
Targeted learning

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10.1007/s12561-020-09274-3

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abstract = "The TechStep study is an ongoing randomized controlled trial in HIV-negative transgender youths and young adults, which will evaluate the efficacy of mobile health interventions for reducing risk behaviors. Several mobile interventions are available, which complicates the design. To evaluate different combinations of mHealth interventions, TechStep is utilizing a sequentially randomized design. In this work, we discuss the motivation for this design, propose robust methodology for the analysis of the trial, and evaluate the methodology via simulation.",

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AU - Hudgens, Michael

PY - 2020/12/1

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KW - MHealth

KW - Randomized trial

KW - SMART

KW - Targeted learning

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Design and Analysis Considerations for a Sequentially Randomized HIV Prevention Trial

Abstract

Keywords

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