Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

Georgina L. Ryland; Masayuki Umeda; Linda Holmfeldt; Sören Lehmann; Morten Krogh Herlin; Jing Ma; Mahsa Khanlari; Jeffrey E. Rubnitz; Rhonda E. Ries; Hansen J. Kosasih; Paul G. Ekert; Hwee Ngee Goh; Ing S. Tiong; Sean M. Grimmond; Claudia Haferlach; Ryan B. Day; Timothy J. Ley; Soheil Meshinchi; Xiaotu Ma; Piers Blombery; Jeffery M. Klco

doi:10.1182/blood.2022017874

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

Georgina L. Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Herlin, Jing Ma, Mahsa Khanlari, Jeffrey E. Rubnitz, Rhonda E. Ries, Hansen J. Kosasih, Paul G. Ekert, Hwee Ngee Goh, Ing S. Tiong, Sean M. Grimmond, Claudia Haferlach, Ryan B. Day, Timothy J. Ley, Soheil Meshinchi, Xiaotu Ma, Piers BlomberyJeffery M. Klco

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	800-805
Number of pages	6
Journal	Blood
Volume	141
Issue number	7
DOIs	https://doi.org/10.1182/blood.2022017874
State	Published - Feb 16 2023

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10.1182/blood.2022017874

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Ryland, G. L., Umeda, M., Holmfeldt, L., Lehmann, S., Herlin, M. K., Ma, J., Khanlari, M., Rubnitz, J. E., Ries, R. E., Kosasih, H. J., Ekert, P. G., Goh, H. N., Tiong, I. S., Grimmond, S. M., Haferlach, C., Day, R. B., Ley, T. J., Meshinchi, S., Ma, X., ... Klco, J. M. (2023). Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions. Blood, 141(7), 800-805. https://doi.org/10.1182/blood.2022017874

@article{86ea8e39c57a46e68058b2f14fa0dea1,

title = "Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions",

author = "Ryland, {Georgina L.} and Masayuki Umeda and Linda Holmfeldt and S{\"o}ren Lehmann and Herlin, {Morten Krogh} and Jing Ma and Mahsa Khanlari and Rubnitz, {Jeffrey E.} and Ries, {Rhonda E.} and Kosasih, {Hansen J.} and Ekert, {Paul G.} and Goh, {Hwee Ngee} and Tiong, {Ing S.} and Grimmond, {Sean M.} and Claudia Haferlach and Day, {Ryan B.} and Ley, {Timothy J.} and Soheil Meshinchi and Xiaotu Ma and Piers Blombery and Klco, {Jeffery M.}",

note = "Funding Information: The authors thank all patients and their families from all participating institutions for their contribution of the biological specimens used in this study. This work was supported by grants from the Wilson Centre for Blood Cancer Genomics and the Snowdome Foundation, as well as the American Lebanese and Syrian Associated Charities of St. Jude Children's Research Hospital. The authors also gratefully acknowledge the Haematology Tissue Bank (Peter MacCallum Cancer Centre/Royal Melbourne Hospital) for assistance with sample collection and the Genomics Core Facility and Genomics Platform Group (University of Melbourne Centre for Cancer Research) for sequencing and analysis support, as well as the Biorepository and the Hartwell Center for Bioinformatics and Biotechnology at St. Jude Children's Research Center (P30 CA021765, Cancer Center Support Grant). Tumor samples and coded data were supplied by the Children's Cancer Centre Biobank at the Murdoch Children's Research Institute and The Royal Children's Hospital (mcri.edu.au/research/projects/childrens-cancer-centre-biobank). The establishment and running of the Children's Cancer Centre is made possible through generous support by Cancer In Kids @ RCH (www.cika.org.au), The Royal Children's Hospital Foundation, and the Murdoch Children's Research Institute. P.G.E. acknowledges the support of the Samuel Nissen Charitable Foundation and the Leukemia and Lymphoma Society USA Specialized Center of Research (SCOR) Project Grant “Apoptosis Controllers.” J.M.K. holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund and is a previous recipient of the V Foundation Scholar Award (Pediatric). This research content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Contribution: G.R. M.U. P.B. and J.M.K. conceived of the project; G.R. M.U. L.H. S.L. M.K.H. J.M. M.K. J.E.R. H.J.K. P.G.E. H.G. I.S.T. S.M.G. C.H. R.B.D. T.J.L. S.M. X.M. P.B. and J.M.K. identified cases and provided genomic data and clinical information; G.R. M.U. J.M. and X.M. analyzed genomic data and collated clinical information; G.R. M.U. P.B. and J.M.K. wrote the first version of the manuscript; all authors reviewed and approved the final version of the manuscript. Funding Information: This work was supported by grants from the Wilson Centre for Blood Cancer Genomics and the Snowdome Foundation , as well as the American Lebanese and Syrian Associated Charities of St. Jude Children's Research Hospital . The authors also gratefully acknowledge the Haematology Tissue Bank (Peter MacCallum Cancer Centre/Royal Melbourne Hospital) for assistance with sample collection and the Genomics Core Facility and Genomics Platform Group (University of Melbourne Centre for Cancer Research) for sequencing and analysis support, as well as the Biorepository and the Hartwell Center for Bioinformatics and Biotechnology at St. Jude Children{\textquoteright}s Research Center (P30 CA021765, Cancer Center Support Grant). Tumor samples and coded data were supplied by the Children{\textquoteright}s Cancer Centre Biobank at the Murdoch Children{\textquoteright}s Research Institute and The Royal Children{\textquoteright}s Hospital (mcri.edu.au/research/projects/childrens-cancer-centre-biobank). The establishment and running of the Children{\textquoteright}s Cancer Centre is made possible through generous support by Cancer In Kids @ RCH ( www.cika.org.au ), The Royal Children{\textquoteright}s Hospital Foundation, and the Murdoch Children{\textquoteright}s Research Institute. P.G.E. acknowledges the support of the Samuel Nissen Charitable Foundation and the Leukemia and Lymphoma Society USA Specialized Center of Research (SCOR) Project Grant “Apoptosis Controllers.” J.M.K. holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund and is a previous recipient of the V Foundation Scholar Award (Pediatric). ",

year = "2023",

month = feb,

day = "16",

doi = "10.1182/blood.2022017874",

language = "English",

volume = "141",

pages = "800--805",

journal = "Blood",

issn = "0006-4971",

number = "7",

}

Ryland, GL, Umeda, M, Holmfeldt, L, Lehmann, S, Herlin, MK, Ma, J, Khanlari, M, Rubnitz, JE, Ries, RE, Kosasih, HJ, Ekert, PG, Goh, HN, Tiong, IS, Grimmond, SM, Haferlach, C, Day, RB , Ley, TJ, Meshinchi, S, Ma, X, Blombery, P & Klco, JM 2023, 'Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions', Blood, vol. 141, no. 7, pp. 800-805. https://doi.org/10.1182/blood.2022017874

TY - JOUR

T1 - Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

AU - Ryland, Georgina L.

AU - Umeda, Masayuki

AU - Holmfeldt, Linda

AU - Lehmann, Sören

AU - Herlin, Morten Krogh

AU - Ma, Jing

AU - Khanlari, Mahsa

AU - Rubnitz, Jeffrey E.

AU - Ries, Rhonda E.

AU - Kosasih, Hansen J.

AU - Ekert, Paul G.

AU - Goh, Hwee Ngee

AU - Tiong, Ing S.

AU - Grimmond, Sean M.

AU - Haferlach, Claudia

AU - Day, Ryan B.

AU - Ley, Timothy J.

AU - Meshinchi, Soheil

AU - Ma, Xiaotu

AU - Blombery, Piers

AU - Klco, Jeffery M.

N1 - Funding Information: The authors thank all patients and their families from all participating institutions for their contribution of the biological specimens used in this study. This work was supported by grants from the Wilson Centre for Blood Cancer Genomics and the Snowdome Foundation, as well as the American Lebanese and Syrian Associated Charities of St. Jude Children's Research Hospital. The authors also gratefully acknowledge the Haematology Tissue Bank (Peter MacCallum Cancer Centre/Royal Melbourne Hospital) for assistance with sample collection and the Genomics Core Facility and Genomics Platform Group (University of Melbourne Centre for Cancer Research) for sequencing and analysis support, as well as the Biorepository and the Hartwell Center for Bioinformatics and Biotechnology at St. Jude Children's Research Center (P30 CA021765, Cancer Center Support Grant). Tumor samples and coded data were supplied by the Children's Cancer Centre Biobank at the Murdoch Children's Research Institute and The Royal Children's Hospital (mcri.edu.au/research/projects/childrens-cancer-centre-biobank). The establishment and running of the Children's Cancer Centre is made possible through generous support by Cancer In Kids @ RCH (www.cika.org.au), The Royal Children's Hospital Foundation, and the Murdoch Children's Research Institute. P.G.E. acknowledges the support of the Samuel Nissen Charitable Foundation and the Leukemia and Lymphoma Society USA Specialized Center of Research (SCOR) Project Grant “Apoptosis Controllers.” J.M.K. holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund and is a previous recipient of the V Foundation Scholar Award (Pediatric). This research content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Contribution: G.R. M.U. P.B. and J.M.K. conceived of the project; G.R. M.U. L.H. S.L. M.K.H. J.M. M.K. J.E.R. H.J.K. P.G.E. H.G. I.S.T. S.M.G. C.H. R.B.D. T.J.L. S.M. X.M. P.B. and J.M.K. identified cases and provided genomic data and clinical information; G.R. M.U. J.M. and X.M. analyzed genomic data and collated clinical information; G.R. M.U. P.B. and J.M.K. wrote the first version of the manuscript; all authors reviewed and approved the final version of the manuscript. Funding Information: This work was supported by grants from the Wilson Centre for Blood Cancer Genomics and the Snowdome Foundation , as well as the American Lebanese and Syrian Associated Charities of St. Jude Children's Research Hospital . The authors also gratefully acknowledge the Haematology Tissue Bank (Peter MacCallum Cancer Centre/Royal Melbourne Hospital) for assistance with sample collection and the Genomics Core Facility and Genomics Platform Group (University of Melbourne Centre for Cancer Research) for sequencing and analysis support, as well as the Biorepository and the Hartwell Center for Bioinformatics and Biotechnology at St. Jude Children’s Research Center (P30 CA021765, Cancer Center Support Grant). Tumor samples and coded data were supplied by the Children’s Cancer Centre Biobank at the Murdoch Children’s Research Institute and The Royal Children’s Hospital (mcri.edu.au/research/projects/childrens-cancer-centre-biobank). The establishment and running of the Children’s Cancer Centre is made possible through generous support by Cancer In Kids @ RCH ( www.cika.org.au ), The Royal Children’s Hospital Foundation, and the Murdoch Children’s Research Institute. P.G.E. acknowledges the support of the Samuel Nissen Charitable Foundation and the Leukemia and Lymphoma Society USA Specialized Center of Research (SCOR) Project Grant “Apoptosis Controllers.” J.M.K. holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund and is a previous recipient of the V Foundation Scholar Award (Pediatric).

PY - 2023/2/16

Y1 - 2023/2/16

UR - http://www.scopus.com/inward/record.url?scp=85147745812&partnerID=8YFLogxK

U2 - 10.1182/blood.2022017874

DO - 10.1182/blood.2022017874

M3 - Article

C2 - 36179268

AN - SCOPUS:85147745812

SN - 0006-4971

VL - 141

SP - 800

EP - 805

JO - Blood

JF - Blood

IS - 7

ER -

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

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