Dermatologic Events Associated with the Anti-CCR4 Antibody Mogamulizumab: Characterization and Management

Amy C.M. Musiek, Kerri E. Rieger, Martine Bagot, Jennifer N. Choi, David C. Fisher, Joan Guitart, Paul L. Haun, Steven M. Horwitz, Auris Onn Lay Huen, Bernice Y. Kwong, Mario E. Lacouture, Sarah J. Noor, Alain H. Rook, Lucia Seminario-Vidal, Maarten H. Vermeer, Youn H. Kim

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The CCR4-directed monoclonal antibody mogamulizumab has been shown to significantly improve progression-free survival and overall response rate compared with vorinostat in adults with relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS). One of the most common adverse events seen with mogamulizumab in MF/SS patients is rash. Because of the protean nature of MF/SS and the variable clinical and histopathological features of mogamulizumab-associated rash, healthcare providers may have difficulty distinguishing rash from disease, and may not be aware of appropriate treatment strategies for this generally manageable adverse event. The objective of this report was to combine results from published literature with experiences and recommendations from multiple investigators and institutions into clinical best practice recommendations to assist healthcare providers in identifying and managing mogamulizumab-associated rash. Optimal management, which includes biopsy confirmation and steroid treatment, requires a multidisciplinary approach among oncology, dermatology, and pathology practitioners. Infographic: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)29-40
Number of pages12
JournalDermatology and Therapy
Volume12
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Cutaneous T-cell lymphoma
  • Eruption
  • Mogamulizumab
  • Mycosis fungoides
  • Rash
  • Sézary syndrome

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