TY - JOUR
T1 - Dermatologic Disorders Associated With Chronic Hepatitis C
T2 - Effect of Interferon Therapy
AU - Berk, David R.
AU - Mallory, Susan Bayliss
AU - Keeffe, Emmet B.
AU - Ahmed, Aijaz
PY - 2007/2
Y1 - 2007/2
N2 - Chronic hepatitis C virus infection (HCV) is associated with extrahepatic manifestations, including such dermatologic conditions as mixed cryoglobulinemia, porphyria cutanea tarda, and lichen planus. Patients with chronic HCV and extrahepatic manifestations are often excluded from clinical trials evaluating interferon (IFN) therapy due to concerns about poor response, adverse events, and toxicity. Thus, data regarding the efficacy of IFN not only on the underlying chronic HCV, but also on extrahepatic manifestations, are limited in these patients. Case reports suggest that the response of dermatologic extrahepatic manifestations to IFN in patients with chronic HCV is highly variable. This review summarizes available data on dermatologic conditions associated with chronic HCV and their response to IFN therapy.
AB - Chronic hepatitis C virus infection (HCV) is associated with extrahepatic manifestations, including such dermatologic conditions as mixed cryoglobulinemia, porphyria cutanea tarda, and lichen planus. Patients with chronic HCV and extrahepatic manifestations are often excluded from clinical trials evaluating interferon (IFN) therapy due to concerns about poor response, adverse events, and toxicity. Thus, data regarding the efficacy of IFN not only on the underlying chronic HCV, but also on extrahepatic manifestations, are limited in these patients. Case reports suggest that the response of dermatologic extrahepatic manifestations to IFN in patients with chronic HCV is highly variable. This review summarizes available data on dermatologic conditions associated with chronic HCV and their response to IFN therapy.
UR - http://www.scopus.com/inward/record.url?scp=33846813689&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2006.06.010
DO - 10.1016/j.cgh.2006.06.010
M3 - Review article
C2 - 16919505
AN - SCOPUS:33846813689
VL - 5
SP - 142
EP - 151
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
SN - 1542-3565
IS - 2
ER -