Abstract
Mok et al. identify niche precursors during progenitor and niche formation in mouse embryonic hair follicles. Population-based and single-cell transcriptomics show that unclustered dermal condensate precursors are at a transitional fibroblast-to-DC state marked by successive waves of transcription factor and signaling molecule expression. Niche fate acquisition is not “pre-programmed” and requires placode progenitor-derived FGF20.
Original language | English |
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Pages (from-to) | 32-48.e5 |
Journal | Developmental cell |
Volume | 48 |
Issue number | 1 |
DOIs | |
State | Published - Jan 7 2019 |
Keywords
- cell fate specification
- dermal condensate precursors
- dermal papilla
- hair follicle formation
- hair follicle morphogenesis
- placode progenitors
- single cell
- stem cell niche