Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent

Ka Wai Mok, Nivedita Saxena, Nicholas Heitman, Laura Grisanti, Devika Srivastava, Mauro J. Muraro, Tina Jacob, Rachel Sennett, Zichen Wang, Yutao Su, Lu M. Yang, Avi Ma'ayan, David M. Ornitz, Maria Kasper, Michael Rendl

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Mok et al. identify niche precursors during progenitor and niche formation in mouse embryonic hair follicles. Population-based and single-cell transcriptomics show that unclustered dermal condensate precursors are at a transitional fibroblast-to-DC state marked by successive waves of transcription factor and signaling molecule expression. Niche fate acquisition is not “pre-programmed” and requires placode progenitor-derived FGF20.

Original languageEnglish
Pages (from-to)32-48.e5
JournalDevelopmental cell
Volume48
Issue number1
DOIs
StatePublished - Jan 7 2019

Keywords

  • cell fate specification
  • dermal condensate precursors
  • dermal papilla
  • hair follicle formation
  • hair follicle morphogenesis
  • placode progenitors
  • single cell
  • stem cell niche

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