Derivation of the diastolic left ventricular wall-thinning to transmitral flow-velocity relation: Validation by model-based image processing

Mark W. Sessoms, Jonathan M. Milde, Jennifer B. Lisauskas, Sandor J. Kovacs

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

The echocardiographically measured maximal rate of left ventricular (LV) wall-thinning in early diastole has been proposed as a new index of diastolic function. However, its causal relationship to transmitral filling velocity (Doppler E-waves) has not been established. We derived the ventricular wall-thinning to filling-velocity relation, using the constant volume attribute of the 4-chamber heart. Left atrio-ventricular geometry was modeled as a constant volume cylinder having a semi-ellipsoid apex and constant external surface. For validation E-wave and color M-Mode images of LV wall thinning were compared to the model predicted filling-velocity to wall-thinning relation. Excellent agreement was observed. We conclude that reasonable assumptions of LV geometry and conservation of volume establish the LV wall-thinning to filling-velocity (Doppler E-wave) relation. Hence, a global, wall-thinning derived diastolic function index is derivable from the transmitral flow velocity (the Doppler E-wave).

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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