@inproceedings{7a71dc2a4da44201858fc86c2430c618,
title = "Derivation of the diastolic left ventricular wall-thinning to transmitral flow-velocity relation: Validation by model-based image processing",
abstract = "The echocardiographically measured maximal rate of left ventricular (LV) wall-thinning in early diastole has been proposed as a new index of diastolic function. However, its causal relationship to transmitral filling velocity (Doppler E-waves) has not been established. We derived the ventricular wall-thinning to filling-velocity relation, using the constant volume attribute of the 4-chamber heart. Left atrio-ventricular geometry was modeled as a constant volume cylinder having a semi-ellipsoid apex and constant external surface. For validation E-wave and color M-Mode images of LV wall thinning were compared to the model predicted filling-velocity to wall-thinning relation. Excellent agreement was observed. We conclude that reasonable assumptions of LV geometry and conservation of volume establish the LV wall-thinning to filling-velocity (Doppler E-wave) relation. Hence, a global, wall-thinning derived diastolic function index is derivable from the transmitral flow velocity (the Doppler E-wave).",
author = "Sessoms, {Mark W.} and Milde, {Jonathan M.} and Lisauskas, {Jennifer B.} and Kovacs, {Sandor J.}",
year = "1999",
month = dec,
day = "1",
language = "English",
isbn = "0780356756",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
note = "null ; Conference date: 13-10-1999 Through 16-10-1999",
}