Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

Finn J. Hawkins, Shingo Suzuki, Mary Lou Beermann, Cristina Barillà, Ruobing Wang, Carlos Villacorta-Martin, Andrew Berical, J. C. Jean, Jake Le Suer, Taylor Matte, Chantelle Simone-Roach, Yang Tang, Thorsten M. Schlaeger, Ana M. Crane, Nadine Matthias, Sarah X.L. Huang, Scott H. Randell, Joshua Wu, Jason R. Spence, Gianni CarraroBarry R. Stripp, Andras Rab, Eric J. Sorsher, Amjad Horani, Steven L. Brody, Brian R. Davis, Darrell N. Kotton

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Hawkins and colleagues report a directed differentiation protocol enabling the derivation of airway basal cells (“iBCs”) from human iPSCs. iBCs recapitulate hallmark stem cell properties of primary basal cells, including self-renewal and multi-lineage differentiation, thus enabling modeling of airway diseases in vitro and repopulation of tracheal xenografts in vivo.

Original languageEnglish
Pages (from-to)79-95.e8
JournalCell Stem Cell
Volume28
Issue number1
DOIs
StatePublished - Jan 7 2021

Keywords

  • airway regeneration
  • basal cells
  • directed differentiation
  • induced pluripotent stem cells

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