Depressive Symptoms and Risk of Type 2 Diabetes in Women

Cassandra Arroyo, Frank B. Hu, Louise M. Ryan, Ichiro Kawachi, Graham A. Colditz, Frank E. Speizer, Joann Manson

Research output: Contribution to journalArticle

125 Scopus citations

Abstract

OBJECTIVE - To explore the relationship between depressive symptoms and incidence of type 2 diabetes in women. RESEARCH DESIGN AND METHODS - We conducted an analysis of 72,178 female nurses aged 45-72 years who did not have diagnosed diabetes and who answered the Medical Outcomes Study 36-Item Short-Form Health Status Survey (SF-36) at baseline in 1992. We calculated relative risks (RR) of type 2 diabetes for women with presence of depressive symptoms (i.e., Five-Item Mental Health Index [MHI-5] score >52). RESULTS - During 4 years of follow-up (282,317 person-years), 973 incident cases of type 2 diabetes were documented. Age-adjusted RR of developing type 2 diabetes for women with presence of depressive symptoms was 1.55 (95% CI 1.27-1.90). Additional adjustment for BMI resulted in a RR of developing type 2 diabetes of 1.36 (1.11-1.67). The multivariate RR of developing type 2 diabetes was 1.22 (1.00-1.50). After excluding women diagnosed with diabetes between 1992 and 1994, 472 incident cases of type 2 diabetes were documented for the follow-up period from 1994 to 1996 (148,889 person-years). The multivariate RR of developing type 2 diabetes for women with depressive symptoms was 1.29 (0.96-1.72). CONCLUSIONS - Our data suggest that depressive symptoms are associated with a modest increase in the risk of type 2 diabetes.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalDiabetes care
Volume27
Issue number1
DOIs
StatePublished - Jan 2004

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    Arroyo, C., Hu, F. B., Ryan, L. M., Kawachi, I., Colditz, G. A., Speizer, F. E., & Manson, J. (2004). Depressive Symptoms and Risk of Type 2 Diabetes in Women. Diabetes care, 27(1), 129-133. https://doi.org/10.2337/diacare.27.1.129