Depolarization of the conductance-voltage relationship in the Na_V1.5 mutant, E1784K, is due to altered fast inactivation

Keyphrases

• Depolarization 100%
• Nav1.5 100%
• Conductance-voltage 100%
• Fast Inactivation 100%
• Membrane Potential 80%
• Voltage Dependence 40%
• Conductance 40%
• Hyperpolarized 40%
• Voltage Sensor 40%
• Channel Conductance 40%
• Gate Charge 40%
• Extracellular pH 20%
• Voltage-gated Sodium Channel 20%
• Voltage Clamp 20%
• Xenopus Oocytes 20%
• Long QT Syndrome 20%
• Brugada Syndrome 20%
• Ionic Current 20%
• Fluorimetry 20%
• Rate Dependence 20%
• Gate Current 20%
• Charge-shift 20%
• Ionic Gating 20%

Neuroscience

• Nav1.5 100%
• Membrane Potential 100%
• Long QT Syndrome 25%
• Voltage Clamp 25%
• Sodium Channel Nav1.5 25%
• Brugada Syndrome 25%