Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus

David Olagnier, Donatella Amatore, Luciano Castiello, Matteo Ferrari, Enrico Palermo, Michael S. Diamond, Anna Teresa Palamara, John Hiscott

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Dengue is the leading mosquito-transmitted viral infection in the world. There are more than 390 million new infections annually; while the majority of infected individuals are asymptomatic or develop a self-limited dengue fever, up to 1 million clinical cases develop severe manifestations, including dengue hemorrhagic fever and shock syndrome, resulting in ~25,000 deaths annually, mainly in children. Gaps in our understanding of the mechanisms that contribute to dengue infection and immunopathogenesis have hampered the development of vaccines and antiviral agents. Some of these limitations are highlighted by the explosive re-emergence of another arthropod-borne flavivirus—Zika virus—spread by the same vector, the Aedes aegypti mosquito, that also carries dengue, yellow fever and chikungunya viruses. This review will discuss the early virus–host interactions in dengue infection, with emphasis on the interrelationship between oxidative stress and innate immune pathways, and will provide insight as to how lessons learned from dengue research may expedite therapeutic strategies for Zika virus.

Original languageEnglish
Pages (from-to)3429-3448
Number of pages20
JournalJournal of Molecular Biology
Issue number17
StatePublished - Aug 28 2016


  • Zika
  • dengue
  • innate immunity
  • oxidative stress
  • pathogenesis


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