Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice

Vanessa Salazar, Brett W. Jagger, Juthathip Mongkolsapaya, Katherine E. Burgomaster, Wanwisa Dejnirattisai, Emma S. Winkler, Estefania Fernandez, Christopher A. Nelson, Daved H. Fremont, Theodore C. Pierson, James E. Crowe, Gavin R. Screaton, Michael S. Diamond

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Salazar et al. show that SPOV, the flavivirus most closely related to ZIKV, infects mice when type I interferon signaling is blocked. SPOV causes ankle swelling and infection in the foot, which is more typical of alphaviruses. Human antibodies from ZIKV or DENV subjects protect against lethal SPOV challenge.

Original languageEnglish
Pages (from-to)1585-1597.e4
JournalCell Reports
Volume26
Issue number6
DOIs
StatePublished - Feb 5 2019

Keywords

  • Dengue virus
  • Spondweni virus
  • Zika virus
  • antibody therapy
  • arthritis
  • flavivirus
  • immunity
  • pathogenesis

Fingerprint

Dive into the research topics of 'Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice'. Together they form a unique fingerprint.

Cite this