@article{dcfdee139316436980371d74ae44df49,
title = "Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice",
abstract = "Salazar et al. show that SPOV, the flavivirus most closely related to ZIKV, infects mice when type I interferon signaling is blocked. SPOV causes ankle swelling and infection in the foot, which is more typical of alphaviruses. Human antibodies from ZIKV or DENV subjects protect against lethal SPOV challenge.",
keywords = "Dengue virus, Spondweni virus, Zika virus, antibody therapy, arthritis, flavivirus, immunity, pathogenesis",
author = "Vanessa Salazar and Jagger, {Brett W.} and Juthathip Mongkolsapaya and Burgomaster, {Katherine E.} and Wanwisa Dejnirattisai and Winkler, {Emma S.} and Estefania Fernandez and Nelson, {Christopher A.} and Fremont, {Daved H.} and Pierson, {Theodore C.} and Crowe, {James E.} and Screaton, {Gavin R.} and Diamond, {Michael S.}",
note = "Funding Information: This work was supported by grants from the NIH (R01 AI073755, R01 AI127828, and R01 HD091218 to M.S.D.; R01 AI127828 to M.S.D. and J.E.C.; T32 AI007163 to E.F.; T32 AI007172 to B.W.J.; and HHSN272201200026C [CSGID] to D.H.F.), the intramural research program of NIAID (T.C.P.), Wellcome Trust to G.R.S., MRC-NEWTON UK to J.M., and The National Institute for Health Research Biomedical Research Centre funding scheme UK. We thank Bin Cao and Indira Mysorekar for tissue processing and Julie Fox for advice on statistical analysis. Funding Information: This work was supported by grants from the NIH ( R01 AI073755 , R01 AI127828 , and R01 HD091218 to M.S.D.; R01 AI127828 to M.S.D. and J.E.C.; T32 AI007163 to E.F.; T32 AI007172 to B.W.J.; and HHSN272201200026C [CSGID] to D.H.F.), the intramural research program of NIAID (T.C.P.), Wellcome Trust to G.R.S., MRC-NEWTON UK to J.M., and The National Institute for Health Research Biomedical Research Centre funding scheme UK. We thank Bin Cao and Indira Mysorekar for tissue processing and Julie Fox for advice on statistical analysis. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = feb,
day = "5",
doi = "10.1016/j.celrep.2019.01.052",
language = "English",
volume = "26",
pages = "1585--1597.e4",
journal = "Cell Reports",
issn = "2211-1247",
number = "6",
}