Dendritic morphology of pyramidal neurons in the chimpanzee neocortex: Regional specializations and comparison to humans

Serena Bianchi, Cheryl D. Stimpson, Amy L. Bauernfeind, Steven J. Schapiro, Wallace B. Baze, Mark J. McArthur, Ellen Bronson, William D. Hopkins, Katerina Semendeferi, Bob Jacobs, Patrick R. Hof, Chet C. Sherwood

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Abstract

The primate cerebral cortex is characterized by regional variation in the structure of pyramidal neurons, with more complex dendritic arbors and greater spine density observed in prefrontal compared with sensory and motor cortices. Although there are several investigations in humans and other primates, virtually nothing is known about regional variation in the morphology of pyramidal neurons in the cerebral cortex of great apes, humans' closest living relatives. The current study uses the rapid Golgi stain to quantify the dendritic structure of layer III pyramidal neurons in 4 areas of the chimpanzee cerebral cortex: Primary somatosensory (area 3b), primary motor (area 4), prestriate visual (area 18), and prefrontal (area 10) cortex. Consistent with previous studies in humans and macaque monkeys, pyramidal neurons in the prefrontal cortex of chimpanzees exhibit greater dendritic complexity than those in other cortical regions, suggesting that prefrontal cortical evolution in primates is characterized by increased potential for integrative connectivity. Compared with chimpanzees, the pyramidal neurons of humans had significantly longer and more branched dendritic arbors in all cortical regions.

Original languageEnglish
Pages (from-to)2429-2436
Number of pages8
JournalCerebral Cortex
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2013

Keywords

  • Area 10
  • Dendrites
  • Evolution
  • Golgi
  • Primate cerebral cortex

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    Bianchi, S., Stimpson, C. D., Bauernfeind, A. L., Schapiro, S. J., Baze, W. B., McArthur, M. J., Bronson, E., Hopkins, W. D., Semendeferi, K., Jacobs, B., Hof, P. R., & Sherwood, C. C. (2013). Dendritic morphology of pyramidal neurons in the chimpanzee neocortex: Regional specializations and comparison to humans. Cerebral Cortex, 23(10), 2429-2436. https://doi.org/10.1093/cercor/bhs239