TY - JOUR
T1 - Dendritic cells in antifungal immunity and vaccine design
AU - Roy, René M.
AU - Klein, Bruce S.
N1 - Funding Information:
This work was supported by grants from the USPHS (AI35681 and AI40996 to B.K.; NIEHS T32ES007015 and F30ES019048 to R.R.). We thank Carrie Roy for her assistance with graphic design and illustration.
PY - 2012/5/17
Y1 - 2012/5/17
N2 - Life-threatening fungal infections have increased in recent years while treatment options remain limited. The development of vaccines against fungal pathogens represents a key advance sorely needed to combat the increasing fungal disease threat. Dendritic cells (DC) are uniquely able to shape antifungal immunity by initiating and modulating naive T cell responses. Targeting DC may allow for the generation of potent vaccines against fungal pathogens. In the context of antifungal vaccine design, we describe the characteristics of the varied DC subsets, how DC recognize fungi, their function in immunity against fungal pathogens, and how DC can be targeted in order to create new antifungal vaccines. Ongoing studies continue to highlight the critical role of DC in antifungal immunity and will help guide DC-based vaccine strategies.
AB - Life-threatening fungal infections have increased in recent years while treatment options remain limited. The development of vaccines against fungal pathogens represents a key advance sorely needed to combat the increasing fungal disease threat. Dendritic cells (DC) are uniquely able to shape antifungal immunity by initiating and modulating naive T cell responses. Targeting DC may allow for the generation of potent vaccines against fungal pathogens. In the context of antifungal vaccine design, we describe the characteristics of the varied DC subsets, how DC recognize fungi, their function in immunity against fungal pathogens, and how DC can be targeted in order to create new antifungal vaccines. Ongoing studies continue to highlight the critical role of DC in antifungal immunity and will help guide DC-based vaccine strategies.
UR - http://www.scopus.com/inward/record.url?scp=84861142106&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2012.04.005
DO - 10.1016/j.chom.2012.04.005
M3 - Review article
C2 - 22607797
AN - SCOPUS:84861142106
SN - 1931-3128
VL - 11
SP - 436
EP - 446
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 5
ER -