Dendritic cell subsets in health and disease

Hideki Ueno, Eynav Klechevsky, Rimpei Morita, Caroline Aspord, Tinghua Cao, Toshimichi Matsui, Tiziana Di Pucchio, John Connolly, Joseph W. Fay, Virginia Pascual, A. Karolina Palucka, Jacques Banchereau

Research output: Contribution to journalReview articlepeer-review

369 Scopus citations


The dendritic cell (DC) system of antigen-presenting cells controls immunity and tolerance. DCs initiate and regulate immune responses in a manner that depends on signals they receive from microbes and their cellular environment. They allow the immune system to make qualitatively distinct responses against different microbial infections. DCs are composed of subsets that express different microbial receptors and express different surface molecules and cytokines. Our studies lead us to propose that interstitial (dermal) DCs preferentially activate humoral immunity, whereas Langerhans cells preferentially induce cellular immunity. Alterations of the DC system result in diseases such as autoimmunity, allergy, and cancer. Conversely, DCs can be exploited for vaccination, and novel vaccines that directly target DCs in vivo are being designed.

Original languageEnglish
Pages (from-to)118-142
Number of pages25
JournalImmunological Reviews
Issue number1
StatePublished - Oct 2007


  • Dendritic cells
  • Diseases
  • Human
  • Phagocyte
  • Subsets


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