Dendritic actin filament nucleation causes traveling waves and patches

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The polymerization of actin via branching at a cell membrane containing nucleation-promoting factors is simulated using a stochastic-growth methodology. The polymerized-actin distribution displays three types of behavior: (a) traveling waves, (b) moving patches, and (c) random fluctuations. Increasing actin concentration causes a transition from patches to waves. The waves and patches move by a treadmilling mechanism not involving myosin II. The effects of downregulation of key proteins on actin wave behavior are evaluated.

Original languageEnglish
Article number228102
JournalPhysical Review Letters
Issue number22
StatePublished - Jun 1 2010


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