DEND mutation in Kir6.2 (KCNJ11) reveals a flexible N-terminal region critical for ATP-sensing of the K_ATP channel

Keyphrases

• Glycine 100%
• KATP Channel 100%
• Kir6.2 100%
• KCNJ11 100%
• N-terminal Region 100%
• ATP Detection 100%
• Binding Site 50%
• Non-canonical 50%
• Amino Acids 50%
• Pore-forming Subunit 50%
• Metabolism 50%
• Excitability 50%
• Pancreatic Islets 50%
• N-terminus 50%
• Electrical Activity 50%
• Structural Modeling 50%
• Myocytes 50%
• Developmental Delay 50%
• K+ Channels 50%
• Developmental Epilepsy 50%
• Neonatal Diabetes 50%
• Intolerance 50%
• Induced Fit 50%
• Sensing Mechanism 50%
• ATP-binding Pocket 50%
• Glycine Substitution 50%

Neuroscience

• Adenosine Triphosphate 100%
• Kir6.2 100%
• Adenosine Triphosphate Sensitive Potassium Channel 100%
• Amino Terminal Sequence 100%
• Metabolic Pathway 11%
• Excitability 11%
• Binding Site 11%
• Potassium Channel 11%
• Amino Acid 11%
• Myocyte 11%
• Inwardly Rectifying Potassium Channel Subunit Kir6.2 11%

Biochemistry, Genetics and Molecular Biology

• Adenosine Triphosphate 100%
• Kir6.2 100%
• N-Terminus 100%
• Adenosine Triphosphate Sensitive Potassium Channel 100%
• Binding Site 11%
• Amino Acids 11%
• Metabolic Pathway 11%
• Excitability 11%
• Potassium Channel 11%
• Electric Activity 11%