Demonstration of two new endogenous "benzodiazepine-like" compounds from brain

Paul J. Marangos, Reena Clark, Andrea M. Martino, Steven M. Paul, Phil Skolnick

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The recent report that purines are competitive inhibitors of specific [3H] diazepam binding to brain membranes has prompted further work concerning the characterization of possible endogenous ligands for the benzodiazepine receptor. In this report, two previously undescribed fractions capable of apparent competitive inhibition of [3H] diazepam binding are reported. Both factors are heat stable and resistant to proteolytic degradation. The larger factor (approximately 700 to 30,000 daltons) is present only in brain and pituitary. The smaller factor (500 to 600 daltons) is found in pituitary, liver, and muscle, but the highest levels are found in brain.

Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalPsychiatry Research
Issue number2
StatePublished - Oct 1979


  • Benzodiazepines
  • bovine brain
  • diazepam
  • endogenous "benzodiazepine-like" compounds
  • receptor binding


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