Delineation of antigen contact residues on an MHC class II molecule

J. Peccoud, P. Dellabona, P. Allen, C. Benoist, D. Mathis

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This report describes a detailed mutational analysis of a major histocompatibility complex class II molecule - the α chain of the A(k) complex. Each residue from 50-79 was replaced by an alanine, and the effects on recognition of A(k) by panels of antibodies and T cells determined. The results provide the strongest existing experimental evidence that the antigen binding site on a class II molecule can be modelled on the crystal structure of a class I molecule. The data have also permitted the delineation of residues that actually contact antigenic peptides.

Original languageEnglish
Pages (from-to)4215-4223
Number of pages9
JournalEMBO Journal
Issue number13
StatePublished - 1990


  • T cell recognition
  • antigen presentation
  • major histocompatibility complex
  • site-specific mutagenesis


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