An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals. Molecular analysis of this abnormality demonstrated a deletion within the fifth intron of the c-sis gene. The normal c-sis gene has an Alu sequence in this region which includes two perfect 130 nucleotide repeated sequences separated by 5 bp. The deleted c-sis allele is missing precisely one copy of the 130 bp repeat and the intervening 5 bp. An identical deletion was also found in DNA from 1 of 13 sporadic meningiomas.

Original languageEnglish
Pages (from-to)1151-1157
Number of pages7
JournalJournal of Clinical Investigation
Issue number4
StatePublished - Oct 1990


  • Oncogene
  • PCR
  • PDGF
  • Recombination
  • Sequence


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