Delaying definitive resection in early stage (I/II) colon cancer appears safe up to 6 weeks

Jesse T. Davidson; Jonathan S. Abelson; Sean C. Glasgow; Steven R. Hunt; Matthew G. Mutch; Paul E. Wise; Matthew L. Silviera; Radhika K. Smith

doi:10.1016/j.amjsurg.2020.11.048

Delaying definitive resection in early stage (I/II) colon cancer appears safe up to 6 weeks

Jesse T. Davidson, Jonathan S. Abelson, Sean C. Glasgow, Steven R. Hunt, Matthew G. Mutch, Paul E. Wise, Matthew L. Silviera, Radhika K. Smith

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: The objective of this study was to determine if there is an impact of surgical delay on 5-year overall survival (OS) from early stage colon cancer, and if so, to define how long surgery can safely be postponed. Methods: Using the NCDB, we compared early (14–30 days) and delayed surgery (31–90 days) in patients with Stage I/II colon cancer. Outcomes included OS at five years and odds of death. Results: Delayed resection conferred a decreased 5-year OS of 73.0% (95% CI, 72.6–73.4), compared to early resection 78.3% (95% CI, 77.9–78.8). When time to surgery was divided into one-week intervals, there was no difference in the odds of death with delay up to 35–41 days (6 weeks), but odds of death increased by 9% per week thereafter. Conclusions: These data support that definitive resection for early stage colon cancer may be safely delayed up to 6 weeks.

Original language	English
Pages (from-to)	402-407
Number of pages	6
Journal	American journal of surgery
Volume	222
Issue number	2
DOIs	https://doi.org/10.1016/j.amjsurg.2020.11.048
State	Published - Aug 2021

Keywords

Cancer outcomes
Colon cancer
Overall survival
Surgical delay

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10.1016/j.amjsurg.2020.11.048

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@article{f9124581cdd54491b5efa55f0ca68ed3,

title = "Delaying definitive resection in early stage (I/II) colon cancer appears safe up to 6 weeks",

abstract = "Background: The objective of this study was to determine if there is an impact of surgical delay on 5-year overall survival (OS) from early stage colon cancer, and if so, to define how long surgery can safely be postponed. Methods: Using the NCDB, we compared early (14–30 days) and delayed surgery (31–90 days) in patients with Stage I/II colon cancer. Outcomes included OS at five years and odds of death. Results: Delayed resection conferred a decreased 5-year OS of 73.0% (95% CI, 72.6–73.4), compared to early resection 78.3% (95% CI, 77.9–78.8). When time to surgery was divided into one-week intervals, there was no difference in the odds of death with delay up to 35–41 days (6 weeks), but odds of death increased by 9% per week thereafter. Conclusions: These data support that definitive resection for early stage colon cancer may be safely delayed up to 6 weeks.",

keywords = "Cancer outcomes, Colon cancer, Overall survival, Surgical delay",

author = "Davidson, {Jesse T.} and Abelson, {Jonathan S.} and Glasgow, {Sean C.} and Hunt, {Steven R.} and Mutch, {Matthew G.} and Wise, {Paul E.} and Silviera, {Matthew L.} and Smith, {Radhika K.}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2021",

month = aug,

doi = "10.1016/j.amjsurg.2020.11.048",

language = "English",

volume = "222",

pages = "402--407",

journal = "American journal of surgery",

issn = "0002-9610",

number = "2",

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TY - JOUR

T1 - Delaying definitive resection in early stage (I/II) colon cancer appears safe up to 6 weeks

AU - Davidson, Jesse T.

AU - Abelson, Jonathan S.

AU - Glasgow, Sean C.

AU - Hunt, Steven R.

AU - Mutch, Matthew G.

AU - Wise, Paul E.

AU - Silviera, Matthew L.

AU - Smith, Radhika K.

PY - 2021/8

Y1 - 2021/8

N2 - Background: The objective of this study was to determine if there is an impact of surgical delay on 5-year overall survival (OS) from early stage colon cancer, and if so, to define how long surgery can safely be postponed. Methods: Using the NCDB, we compared early (14–30 days) and delayed surgery (31–90 days) in patients with Stage I/II colon cancer. Outcomes included OS at five years and odds of death. Results: Delayed resection conferred a decreased 5-year OS of 73.0% (95% CI, 72.6–73.4), compared to early resection 78.3% (95% CI, 77.9–78.8). When time to surgery was divided into one-week intervals, there was no difference in the odds of death with delay up to 35–41 days (6 weeks), but odds of death increased by 9% per week thereafter. Conclusions: These data support that definitive resection for early stage colon cancer may be safely delayed up to 6 weeks.

AB - Background: The objective of this study was to determine if there is an impact of surgical delay on 5-year overall survival (OS) from early stage colon cancer, and if so, to define how long surgery can safely be postponed. Methods: Using the NCDB, we compared early (14–30 days) and delayed surgery (31–90 days) in patients with Stage I/II colon cancer. Outcomes included OS at five years and odds of death. Results: Delayed resection conferred a decreased 5-year OS of 73.0% (95% CI, 72.6–73.4), compared to early resection 78.3% (95% CI, 77.9–78.8). When time to surgery was divided into one-week intervals, there was no difference in the odds of death with delay up to 35–41 days (6 weeks), but odds of death increased by 9% per week thereafter. Conclusions: These data support that definitive resection for early stage colon cancer may be safely delayed up to 6 weeks.

KW - Cancer outcomes

KW - Colon cancer

KW - Overall survival

KW - Surgical delay

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U2 - 10.1016/j.amjsurg.2020.11.048

DO - 10.1016/j.amjsurg.2020.11.048

M3 - Article

C2 - 33602480

AN - SCOPUS:85101377372

SN - 0002-9610

VL - 222

SP - 402

EP - 407

JO - American journal of surgery

JF - American journal of surgery

IS - 2

ER -

Delaying definitive resection in early stage (I/II) colon cancer appears safe up to 6 weeks

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Keywords

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