TY - JOUR
T1 - Delayed recurrence of hepatocellular carcinoma after liver transplantation
T2 - Detection of origin by chromosomal analysis
AU - Al-Joundi, Tammam
AU - Gibson, Sandra
AU - Brunt, Elizabeth M.
AU - Shakil, Obaid
AU - Lee, Randall S.
AU - Di Bisceglie, Adrian M.
PY - 2000/5
Y1 - 2000/5
N2 - We report on a 41-year-old man undergoing liver transplantation for chronic hepatitis C who presented 26 months later with hepatocellular carcinoma. No evidence of hepatocellular carcinoma could be found in the native liver, although features of small cell dysplasia were prominent. Although he had recurrent hepatitis C, the transplanted liver was not cirrhotic. Chromosomal analysis was used to resolve whether this was a de novo tumor or a recurrence of an unsuspected tumor present at the time of transplantation. This male patient had received a liver from a female donor, and in situ hybridization for the Y chromosome showed reactivity in the tumor but not in surrounding nontumorous liver. Thus, this is an example of the use of chromosomal analysis to resolve the origin of a tumor occurring in the transplant setting.
AB - We report on a 41-year-old man undergoing liver transplantation for chronic hepatitis C who presented 26 months later with hepatocellular carcinoma. No evidence of hepatocellular carcinoma could be found in the native liver, although features of small cell dysplasia were prominent. Although he had recurrent hepatitis C, the transplanted liver was not cirrhotic. Chromosomal analysis was used to resolve whether this was a de novo tumor or a recurrence of an unsuspected tumor present at the time of transplantation. This male patient had received a liver from a female donor, and in situ hybridization for the Y chromosome showed reactivity in the tumor but not in surrounding nontumorous liver. Thus, this is an example of the use of chromosomal analysis to resolve the origin of a tumor occurring in the transplant setting.
UR - http://www.scopus.com/inward/record.url?scp=0034078124&partnerID=8YFLogxK
U2 - 10.1053/lv.2000.5202
DO - 10.1053/lv.2000.5202
M3 - Article
C2 - 10827244
AN - SCOPUS:0034078124
VL - 6
SP - 374
EP - 375
JO - Liver Transplantation
JF - Liver Transplantation
SN - 1527-6465
IS - 3
ER -