Delayed recurrence of hepatocellular carcinoma after liver transplantation: Detection of origin by chromosomal analysis

Tammam Al-Joundi, Sandra Gibson, Elizabeth M. Brunt, Obaid Shakil, Randall S. Lee, Adrian M. Di Bisceglie

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We report on a 41-year-old man undergoing liver transplantation for chronic hepatitis C who presented 26 months later with hepatocellular carcinoma. No evidence of hepatocellular carcinoma could be found in the native liver, although features of small cell dysplasia were prominent. Although he had recurrent hepatitis C, the transplanted liver was not cirrhotic. Chromosomal analysis was used to resolve whether this was a de novo tumor or a recurrence of an unsuspected tumor present at the time of transplantation. This male patient had received a liver from a female donor, and in situ hybridization for the Y chromosome showed reactivity in the tumor but not in surrounding nontumorous liver. Thus, this is an example of the use of chromosomal analysis to resolve the origin of a tumor occurring in the transplant setting.

Original languageEnglish
Pages (from-to)374-375
Number of pages2
JournalLiver Transplantation
Volume6
Issue number3
DOIs
StatePublished - May 2000

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