Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness

Edward P. Weiss, Dennis T. Villareal, Ali A. Ehsani, Luigi Fontana, John O. Holloszy

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Serum dehydroepiandrosterone (DHEA) concentrations decrease approximately 80% between ages 25 and 75year. Aging also results in an increase in arterial stiffness, which is an independent predictor of cardiovascular disease (CVD) risk and mortality. Therefore, it is conceivable that DHEA replacement in older adults could reduce arterial stiffness. We sought to determine whether DHEA replacement therapy in older adults reduces carotid augmentation index (AI) and carotid-femoral pulse wave velocity (PWV) as indices of arterial stiffness. A randomized, double-blind trial was conducted to study the effects of 50mgday-1 DHEA replacement on AI (n=92) and PWV (n=51) in women and men aged 65-75year. Inflammatory cytokines and sex hormones were measured in fasting serum. AI decreased in the DHEA group, but not in the placebo group (difference between groups, -6±2 AI units, P=0.002). Pulse wave velocity also decreased (difference between groups, -3.5±1.0ms-1, P=0.001); however, after adjusting for baseline values, the between-group comparison became nonsignificant (P=0.20). The reductions in AI and PWV were accompanied by decreases in inflammatory cytokines (tumor necrosis factor α and IL-6, P<0.05) and correlated with increases in serum DHEAS (r=-0.31 and -0.37, respectively, P<0.05). The reductions in AI also correlated with free testosterone index (r=-0.23, P=0.03). In conclusion, DHEA replacement in elderly men and women improves indices of arterial stiffness. Arterial stiffness increases with age and is an independent risk factor for CVD. Therefore, the improvements observed in this study suggest that DHEA replacement might partly reverse arterial aging and reduce CVD risk.

Original languageEnglish
Pages (from-to)876-884
Number of pages9
JournalAging Cell
Issue number5
StatePublished - Oct 2012


  • Aging
  • Augmentation index
  • Vasculature

Fingerprint Dive into the research topics of 'Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness'. Together they form a unique fingerprint.

Cite this