@article{ff5e3b2257a949d0a3750c1406c0a9d9,
title = "Degradation and covalent cross-linking of glutathione reductase by hemin",
abstract = "Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymatic activity of glutathione reductase is rapidly destroyed. Implications of these findings for a regulatory role of hemin in cell biology are discussed.",
author = "Aft, {Rebecca L.} and Mueller, {Gerald C.}",
note = "Funding Information: The authors thank Mary A. LeMahieu and Mary Jo Markham for their assistancei n the preparationo f the manuscript. This work was supportedb y Grants P30-CA-07175 and POI-CA-23076 from the National Cancer Institute,U SPHS, and NIH Training Grant T32-CA-09~30. Gerald C. Mueller is the recipiento f a Research Career Award, CA-00685 from the National Cancer Institute.",
year = "1985",
month = jun,
day = "3",
doi = "10.1016/0024-3205(85)90312-1",
language = "English",
volume = "36",
pages = "2153--2161",
journal = "Life Sciences",
issn = "0024-3205",
number = "22",
}