Degradation and covalent cross-linking of glutathione reductase by hemin

Rebecca L. Aft, Gerald C. Mueller

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymatic activity of glutathione reductase is rapidly destroyed. Implications of these findings for a regulatory role of hemin in cell biology are discussed.

Original languageEnglish
Pages (from-to)2153-2161
Number of pages9
JournalLife Sciences
Issue number22
StatePublished - Jun 3 1985


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