TY - JOUR
T1 - Deformation of the human brain induced by mild angular head acceleration
AU - Sabet, Arash A.
AU - Christoforou, Eftychios
AU - Zatlin, Benjamin
AU - Genin, Guy M.
AU - Bayly, Philip V.
N1 - Funding Information:
The technical assistance of Richard Nagel and Linda Hood is gratefully acknowledged. Support from NIH grant NS-55951 is gratefully acknowledged. MRI facilities support was provided by National Cancer Institute Small Animal Imaging Resource (SAIR) Program grant R24-CA83060. This work was also funded in part by the US DOT (NHTSA) grant DTNH22-01-H-07551 and the FHA grant FHWA ICRC(1) via the Southern Consortium on Injury Biomechanics.
PY - 2008
Y1 - 2008
N2 - Deformation of the human brain was measured in tagged magnetic resonance images (MRI) obtained dynamically during angular acceleration of the head. This study was undertaken to provide quantitative experimental data to illuminate the mechanics of traumatic brain injury (TBI). Mild angular acceleration was imparted to the skull of a human volunteer inside an MR scanner, using a custom MR-compatible device to constrain motion. A grid of MR "tag" lines was applied to the MR images via spatial modulation of magnetization (SPAMM) in a fast gradient echo imaging sequence. Images of the moving brain were obtained dynamically by synchronizing the imaging process with the motion of the head. Deformation of the brain was characterized quantitatively via Lagrangian strain. Consistent patterns of radial-circumferential shear strain occur in the brain, similar to those observed in models of a viscoelastic gel cylinder subjected to angular acceleration. Strain fields in the brain, however, are clearly mediated by the effects of heterogeneity, divisions between regions of the brain (such as the central fissure and central sulcus) and the brain's tethering and suspension system, including the dura mater, falx cerebri, and tentorium membranes.
AB - Deformation of the human brain was measured in tagged magnetic resonance images (MRI) obtained dynamically during angular acceleration of the head. This study was undertaken to provide quantitative experimental data to illuminate the mechanics of traumatic brain injury (TBI). Mild angular acceleration was imparted to the skull of a human volunteer inside an MR scanner, using a custom MR-compatible device to constrain motion. A grid of MR "tag" lines was applied to the MR images via spatial modulation of magnetization (SPAMM) in a fast gradient echo imaging sequence. Images of the moving brain were obtained dynamically by synchronizing the imaging process with the motion of the head. Deformation of the brain was characterized quantitatively via Lagrangian strain. Consistent patterns of radial-circumferential shear strain occur in the brain, similar to those observed in models of a viscoelastic gel cylinder subjected to angular acceleration. Strain fields in the brain, however, are clearly mediated by the effects of heterogeneity, divisions between regions of the brain (such as the central fissure and central sulcus) and the brain's tethering and suspension system, including the dura mater, falx cerebri, and tentorium membranes.
KW - Angular acceleration
KW - Brain deformation
KW - Brain trauma
KW - Head injury
KW - MRI
KW - Strain
UR - http://www.scopus.com/inward/record.url?scp=38149111093&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2007.09.016
DO - 10.1016/j.jbiomech.2007.09.016
M3 - Article
C2 - 17961577
AN - SCOPUS:38149111093
SN - 0021-9290
VL - 41
SP - 307
EP - 315
JO - Journal of Biomechanics
JF - Journal of Biomechanics
IS - 2
ER -