Deformable anatomical templates for brachytherapy treatment planning in radiotherapy of cervical cancer

G. E. Christensen, J. F. Williamson, K. S.C. Chao, M. I. Miller, F. B. So, M. W. Vannier

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

This paper describes a new method to register serial, volumetric x-ray computed tomography (CT) data sets for tracking soft-tissue deformation caused by insertion of intracavitary brachytherapy applicators to treat cervical cancer. 3D CT scans collected from the same patient with and without a brachytherapy applicator are registered to aid in computation of the radiation dose to tumor and normal tissue. The 3D CT image volume of pelvic anatomy with the applicator is used as an anatomical template which is deformed into the shape of a CT image volume without the applicator. Initial registration is accomplished by rigid alignment of the pelvic bones and non-rigid alignment of gray scale CT data and hand segmentations of the vagina, cervix, bladder, and rectum. A viscous fluid transformation model is used for non-rigid registration to allow for local, non-linear registration of the vagina, cervix, bladder, and rectum without disturbing the rigid registration of the bony pelvis and adjacent structures. Results are presented in which two 3D CT data sets of the same patient - imaged with and without a brachytherapy applicator - are registered.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3168
DOIs
StatePublished - Dec 1 1997
EventVision Geometry VI - San Diego, CA, United States
Duration: Jul 28 1997Jul 28 1997

Keywords

  • Deformable templates
  • Image registration
  • Medical imaging
  • Radiation treatment planning

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