Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions

Joseph L. Price

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

255 Scopus citations

Abstract

The orbitofrontal cortex is often defined topographically as the cortex on the ventral surface of the frontal lobe. Unfortunately, this definition is not consistently used, and it obscures distinct connectional and functional systems within the orbital cortex. It is difficult to interpret data on the orbital cortex that do not take these different systems into account. Analysis of cortico-cortical connections between areas in the orbital and medial prefrontal cortex indicate two distinct networks in this region. One system, called the orbital network, involves most of the areas in the central orbital cortex. The other system, has been called the medial prefrontal network, though it is actually more complex, since it includes areas on the medial wall, in the medial orbital cortex, and in the posterolateral orbital cortex. Some areas in the medial orbital cortex are involved in both networks. Connections to other brain areas support the distinction between the networks. The orbital network receives several sensory inputs, from olfactory cortex, taste cortex, somatic sensory association cortex, and visual association cortex, and is connected with multisensory areas in the ventrolateral prefrontal cortex and perirhinal cortex. The medial network has outputs to the hypothalamus and brain stem and connects to a cortical circuit that includes the rostral part of the superior temporal gyrus and dorsal bank of the superior temporal sulcus, the cingulate and retrosplenial cortex, the entorhinal and posterior parahippocampal cortex, and the dorsomedial prefrontal cortex.

Original languageEnglish
Title of host publicationLinking affect to Action
Subtitle of host publicationCritical Contributions to the Orbitofrontal Cortex
PublisherBlackwell Publishing Inc.
Pages54-71
Number of pages18
ISBN (Print)9781573316835
DOIs
StatePublished - Dec 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1121
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Architectonic areas
  • Cortico-cortical connections
  • Medial prefrontal cortex
  • Medial prefrontal network
  • Mediodorsal thalamus
  • Orbital prefrontal network
  • Periaqueductal gray
  • Ventral striatum

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