TY - JOUR
T1 - Defining alcohol-related phenotypes in humans
T2 - The collaborative study on the genetics of alcoholism
AU - Bierut, Laura Jean
AU - Saccone, Nancy L.
AU - Rice, John P.
AU - Goate, Alison
AU - Foroud, Tatiana
AU - Edenberg, Howard
AU - Almasy, Laura
AU - Conneally, P. Michael
AU - Crowe, Raymond
AU - Hesselbrock, Victor
AU - Li, T. K.
AU - Nurnberger, John
AU - Porjesz, Bernice
AU - Schuckit, Marc A.
AU - Tischfield, Jay
AU - Begleiter, Henri
AU - Reich, Theodore
PY - 2002
Y1 - 2002
N2 - Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COCA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects and their families, with researchers conducting comprehensive psychological, physiological, electrophysiological, and genetic analyses of the participants. These analyses have identified several traits, or phenotypes, that appear to be genetically determined, such as the presence of alcohol dependence, the level of response to alcohol, the presence of coexisting depression, or the maximum number of drinks a person consumes per occasion. Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further.
AB - Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COCA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects and their families, with researchers conducting comprehensive psychological, physiological, electrophysiological, and genetic analyses of the participants. These analyses have identified several traits, or phenotypes, that appear to be genetically determined, such as the presence of alcohol dependence, the level of response to alcohol, the presence of coexisting depression, or the maximum number of drinks a person consumes per occasion. Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further.
KW - AODR (alcohol and other drug related) genetic markers
KW - Aod dependence potential
KW - Aod intake per occasion
KW - Chromosome
KW - Comorbidity
KW - Genetic theory of AODU (alcohol and other drug use)
KW - Genetic trait
KW - Genetic variance
KW - Major depression
KW - Phenotype
UR - http://www.scopus.com/inward/record.url?scp=0042351172&partnerID=8YFLogxK
M3 - Article
C2 - 2003114616
AN - SCOPUS:0042351172
SN - 0090-838X
VL - 26
SP - 208
EP - 213
JO - Alcohol Research and Health
JF - Alcohol Research and Health
IS - 3
ER -