Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes

Francisco A. Tausk; J. Allen McCutchan; Robert D. Schreiber; Phyllis Spechko; Irma Gigli

doi:10.1007/BF01145182

Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes

Francisco A. Tausk
, J. Allen McCutchan
, Robert D. Schreiber
, Phyllis Spechko
, Irma Gigli

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.

Original language	English
Pages (from-to)	81-86
Number of pages	6
Journal	Bioscience Reports
Volume	6
Issue number	1
DOIs	https://doi.org/10.1007/BF01145182
State	Published - Jan 1986

Keywords

AIDS
C3b receptor
CR1

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10.1007/BF01145182

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title = "Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes",

abstract = "The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.",

keywords = "AIDS, C3b receptor, CR1",

author = "Tausk, \{Francisco A.\} and McCutchan, \{J. Allen\} and Schreiber, \{Robert D.\} and Phyllis Spechko and Irma Gigli",

year = "1986",

month = jan,

doi = "10.1007/BF01145182",

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AU - Tausk, Francisco A.

AU - McCutchan, J. Allen

AU - Schreiber, Robert D.

AU - Spechko, Phyllis

AU - Gigli, Irma

PY - 1986/1

Y1 - 1986/1

N2 - The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.

AB - The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.

KW - AIDS

KW - C3b receptor

KW - CR1

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JF - Bioscience Reports

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ER -

Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes

Abstract

Keywords

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