Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes

Francisco A. Tausk; J. Allen McCutchan; Robert D. Schreiber; Phyllis Spechko; Irma Gigli

doi:10.1007/BF01145182

Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes

Francisco A. Tausk, J. Allen McCutchan, Robert D. Schreiber, Phyllis Spechko, Irma Gigli

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6 Scopus citations

Abstract

The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.

Original language	English
Pages (from-to)	81-86
Number of pages	6
Journal	Bioscience Reports
Volume	6
Issue number	1
DOIs	https://doi.org/10.1007/BF01145182
State	Published - Jan 1986

Keywords

AIDS
C3b receptor
CR1

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10.1007/BF01145182

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title = "Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes",

abstract = "The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.",

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AU - Gigli, Irma

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AB - The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.

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Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes

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Keywords

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