Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes

Francisco A. Tausk, J. Allen McCutchan, Robert D. Schreiber, Phyllis Spechko, Irma Gigli

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5 Scopus citations

Abstract

The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X)±standard deviation of 516±136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X=423±156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X=342±154, 9 patients with ARC had X=252±76, and 14 gay men with AIDS had X=173±76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p=<0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalBioscience Reports
Volume6
Issue number1
DOIs
StatePublished - Jan 1986

Keywords

  • AIDS
  • C3b receptor
  • CR1

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