Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model

Yunglin D. Ma, Changwon Park, Haibo Zhao, Kwadwo A. Oduro, Xiaolin Tu, Fanxin Long, Paul M. Allen, Steven L. Teitelbaum, Kyunghee Choi

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis in normal steady states. Using mice undergoing chronic inflammatory arthritis, we investigated the relationship between hematopoiesis and bone homeostasis in pathologic conditions. We demonstrate that mice undergoing chronic inflammatory arthritis displayed osteoporosis resulting from a severe defect in osteoblast function. Despite the defective osteoblast function, however, the hematopoietic stem cells from these mice exhibited normal properties in either long-term repopulation or cell cycling. Therefore, the boneforming capacity of osteoblasts is distinct from their ability to maintain hematopoietic stem cells in chronic in-flammatory conditions.

Original languageEnglish
Pages (from-to)4402-4410
Number of pages9
JournalBlood
Volume114
Issue number20
DOIs
StatePublished - Nov 12 2009

Fingerprint Dive into the research topics of 'Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model'. Together they form a unique fingerprint.

Cite this