Abstract
Defective viral particles are a subpopulation of viral particles that are unable to complete a full replication cycle in the absence of a co-infecting standard virus. They are generated during the replication of plant, arthropod and mammalian viruses, and contain defective viral genomes (DVGs) that result from genomic alterations introduced during viral replication. This chapter focuses on DVGs that retain functional replication promoters and maintain the potential to be replicated when complemented by a co-infecting standard virus. DVGs that are able to interfere with the replication of the standard virus by competing for the viral replication machinery are known as defective interfering (DI) genomes. Defective viral particles can induce antiviral immune responses, promote the survival of a subpopulation of infected cells and affect how the virus spreads. These functions are independent of the replication interference properties of DI genomes.
| Original language | English |
|---|---|
| Title of host publication | Virology |
| Publisher | Wiley Blackwell |
| Pages | 159-196 |
| Number of pages | 38 |
| ISBN (Print) | 9781119818526 |
| DOIs | |
| State | Published - Apr 29 2021 |
Keywords
- Antiviral response
- Defective interfering genomes
- Defective viral genomes
- Defective viral particles
- Viral particles functions