Defective Counterregulation and Hypoglycemia Unawareness in Diabetes. Mechanisms and Emerging Treatments.

Candace M. Reno; Marina Litvin; Amy L. Clark; Simon J. Fisher

doi:10.1016/j.ecl.2012.11.005

Defective Counterregulation and Hypoglycemia Unawareness in Diabetes. Mechanisms and Emerging Treatments.

Candace M. Reno, Marina Litvin, Amy L. Clark, Simon J. Fisher

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

For people with diabetes, hypoglycemia remains the limiting factor in achieving glycemic control. This article reviews recent advances in how the brain senses and responds to hypoglycemia. Novel mechanisms by which individuals with insulin-treated diabetes develop hypoglycemia unawareness and impaired counterregulatory responses are outlined. Prevention strategies for reducing the incidence of hypoglycemia are discussed.

Original language	English
Pages (from-to)	15-38
Number of pages	24
Journal	Endocrinology and Metabolism Clinics of North America
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.ecl.2012.11.005
State	Published - Mar 2013

Keywords

Brain
Counterregulation
Diabetes
Glucose
Hypoglycemia
Hypoglycemia-associated autonomic failure
Hypothalamus
Unawareness

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10.1016/j.ecl.2012.11.005

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abstract = "For people with diabetes, hypoglycemia remains the limiting factor in achieving glycemic control. This article reviews recent advances in how the brain senses and responds to hypoglycemia. Novel mechanisms by which individuals with insulin-treated diabetes develop hypoglycemia unawareness and impaired counterregulatory responses are outlined. Prevention strategies for reducing the incidence of hypoglycemia are discussed.",

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Defective Counterregulation and Hypoglycemia Unawareness in Diabetes. Mechanisms and Emerging Treatments.

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Keywords

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