Decreased cortical thickness & osteopenia in children with diabetes mellitus

J. V. Santiago, W. H. McAlister, S. K. Ratzan, Y. Bussman, M. W. Haymond, G. Shackelford, V. V. Weldon

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


A recent study using the photon absorption technique has revealed a high frequency of significant bone loss in diabetic adults regardless of age or duration of diabetes. In this study 107 diabetic children age 4-18 were studied using cortical bone thickness and skeletal maturation as indicators of bone development. Overall, 25% of all diabetic children had cortical thickness values below the five percent limit for normal children. This was more common in boys than girls and was unrelated to duration of diabetes. A modest increase in delayed skeletal maturation did not account for the cortical thinning and osteopenia observed. The cause of the osteopenia of diabetic children remains an enigma.

Original languageEnglish
Pages (from-to)845-848
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Oct 1977


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