Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

Luigi Fontana; Nicole E. Cummings; Sebastian I. Arriola Apelo; Joshua C. Neuman; Ildiko Kasza; Brian A. Schmidt; Edda Cava; Francesco Spelta; Valeria Tosti; Faizan A. Syed; Emma L. Baar; Nicola Veronese; Sara E. Cottrell; Rachel J. Fenske; Beatrice Bertozzi; Harpreet K. Brar; Terri Pietka; Arnold D. Bullock; Robert S. Figenshau; Gerald L. Andriole; Matthew J. Merrins; Caroline M. Alexander; Michelle E. Kimple; Dudley W. Lamming

doi:10.1016/j.celrep.2016.05.092

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

Luigi Fontana, Nicole E. Cummings, Sebastian I. Arriola Apelo, Joshua C. Neuman, Ildiko Kasza, Brian A. Schmidt, Edda Cava, Francesco Spelta, Valeria Tosti, Faizan A. Syed, Emma L. Baar, Nicola Veronese, Sara E. Cottrell, Rachel J. Fenske, Beatrice Bertozzi, Harpreet K. Brar, Terri Pietka, Arnold D. Bullock, Robert S. Figenshau, Gerald L. AndrioleMatthew J. Merrins, Caroline M. Alexander, Michelle E. Kimple, Dudley W. Lamming

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321 Scopus citations

Abstract

Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.

Original language	English
Pages (from-to)	520-530
Number of pages	11
Journal	Cell Reports
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2016.05.092
State	Published - Jul 12 2016

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10.1016/j.celrep.2016.05.092

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Fontana, L., Cummings, N. E., Arriola Apelo, S. I., Neuman, J. C., Kasza, I., Schmidt, B. A., Cava, E., Spelta, F., Tosti, V., Syed, F. A., Baar, E. L., Veronese, N., Cottrell, S. E., Fenske, R. J., Bertozzi, B., Brar, H. K., Pietka, T., Bullock, A. D., Figenshau, R. S., ... Lamming, D. W. (2016). Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Reports, 16(2), 520-530. https://doi.org/10.1016/j.celrep.2016.05.092

@article{f49c2c8c5b234cbbafd9a7a0c9fcd515,

title = "Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health",

abstract = "Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.",

author = "Luigi Fontana and Cummings, {Nicole E.} and {Arriola Apelo}, {Sebastian I.} and Neuman, {Joshua C.} and Ildiko Kasza and Schmidt, {Brian A.} and Edda Cava and Francesco Spelta and Valeria Tosti and Syed, {Faizan A.} and Baar, {Emma L.} and Nicola Veronese and Cottrell, {Sara E.} and Fenske, {Rachel J.} and Beatrice Bertozzi and Brar, {Harpreet K.} and Terri Pietka and Bullock, {Arnold D.} and Figenshau, {Robert S.} and Andriole, {Gerald L.} and Merrins, {Matthew J.} and Alexander, {Caroline M.} and Kimple, {Michelle E.} and Lamming, {Dudley W.}",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors",

year = "2016",

month = jul,

day = "12",

doi = "10.1016/j.celrep.2016.05.092",

language = "English",

volume = "16",

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Fontana, L, Cummings, NE, Arriola Apelo, SI, Neuman, JC, Kasza, I, Schmidt, BA, Cava, E, Spelta, F, Tosti, V, Syed, FA, Baar, EL, Veronese, N, Cottrell, SE, Fenske, RJ, Bertozzi, B, Brar, HK, Pietka, T, Bullock, AD , Figenshau, RS, Andriole, GL, Merrins, MJ, Alexander, CM, Kimple, ME & Lamming, DW 2016, 'Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health', Cell Reports, vol. 16, no. 2, pp. 520-530. https://doi.org/10.1016/j.celrep.2016.05.092

TY - JOUR

T1 - Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

AU - Fontana, Luigi

AU - Cummings, Nicole E.

AU - Arriola Apelo, Sebastian I.

AU - Neuman, Joshua C.

AU - Kasza, Ildiko

AU - Schmidt, Brian A.

AU - Cava, Edda

AU - Spelta, Francesco

AU - Tosti, Valeria

AU - Syed, Faizan A.

AU - Baar, Emma L.

AU - Veronese, Nicola

AU - Cottrell, Sara E.

AU - Fenske, Rachel J.

AU - Bertozzi, Beatrice

AU - Brar, Harpreet K.

AU - Pietka, Terri

AU - Bullock, Arnold D.

AU - Figenshau, Robert S.

AU - Andriole, Gerald L.

AU - Merrins, Matthew J.

AU - Alexander, Caroline M.

AU - Kimple, Michelle E.

AU - Lamming, Dudley W.

PY - 2016/7/12

Y1 - 2016/7/12

N2 - Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.

AB - Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.

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DO - 10.1016/j.celrep.2016.05.092

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AN - SCOPUS:84992520062

SN - 2211-1247

VL - 16

SP - 520

EP - 530

JO - Cell Reports

JF - Cell Reports

IS - 2

ER -

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

Abstract

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