@article{f49c2c8c5b234cbbafd9a7a0c9fcd515,
title = "Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health",
abstract = "Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.",
author = "Luigi Fontana and Cummings, {Nicole E.} and {Arriola Apelo}, {Sebastian I.} and Neuman, {Joshua C.} and Ildiko Kasza and Schmidt, {Brian A.} and Edda Cava and Francesco Spelta and Valeria Tosti and Syed, {Faizan A.} and Baar, {Emma L.} and Nicola Veronese and Cottrell, {Sara E.} and Fenske, {Rachel J.} and Beatrice Bertozzi and Brar, {Harpreet K.} and Terri Pietka and Bullock, {Arnold D.} and Figenshau, {Robert S.} and Andriole, {Gerald L.} and Merrins, {Matthew J.} and Alexander, {Caroline M.} and Kimple, {Michelle E.} and Lamming, {Dudley W.}",
note = "Funding Information: We would like to thank all the members of the D.W.L., L.F., C.M.A., M.E.K., and M.J.M. labs for their assistance and insight, and the Davis lab for their continual support. We would like to thank Dena Cohen for advice and consultation, Tina Herfel (Envigo) for assistance with the formulation of the amino-acid-defined diets, and the reviewers of this manuscript, who greatly aided us with their suggestions. We thank Kathleen Obert, MS, RD, LD for the photograph of a sample dinner used in the slider image accompanying this manuscript and Clint Thayer for assistance with preparation of the slider image. The D.W.L. lab is supported by a K99/R00 Pathway to Independence Award to D.W.L. from the NIH/National Institute on Aging (AG041765), a New Investigator Program Award from the Wisconsin Partnership Program, and a Glenn Foundation Award for Research in the Biological Mechanisms of Aging, as well as startup funds from the UW-Madison School of Medicine and Public Health and the UW-Madison Department of Medicine. This research was conducted while D.W.L. was an AFAR Research Grant recipient from the American Federation for Aging Research. The L.F. lab is supported by grants from the Bakewell Foundation, the Longer Life Foundation (an RGA/Washington University Partnership), and the National Center for Research Resources (UL1 RR024992). This work was also supported by grants from the American Diabetes Association (1-14-BS-115) and the NIH/NIDDK (R01 DK102598) to M.E.K. The M.J.M. lab is supported in part by a Research Scientist Development Award from the NIH/NIDDK (K01 DK101683) and an Innovative Basic Science Award from the American Diabetes Association (1-16-IBS-212) to M.J.M. S.I.A.A. is supported in part by a fellowship from the American Diabetes Association (1-16-PMF-001). J.C.N. is supported in part by a training grant from the UW Institute on Aging (NIA T32 AG000213). I.K. is supported in part by McArdle Departmental Funds. S.E.C. was supported by the Rural and Urban Scholars in Community Health Program. This work was supported using facilities and resources from the William S. Middleton Memorial Veterans Hospital. This work does not represent the views of the Department of Veterans Affairs or the United States Government. Publisher Copyright: {\textcopyright} 2016 The Authors",
year = "2016",
month = jul,
day = "12",
doi = "10.1016/j.celrep.2016.05.092",
language = "English",
volume = "16",
pages = "520--530",
journal = "Cell Reports",
issn = "2211-1247",
number = "2",
}