Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

Chiara Fenoglio, Elisa Ridolfi, Claudia Cantoni, Milena De Riz, Rossana Bonsi, Maria Serpente, Chiara Villa, Anna M. Pietroboni, Robert T. Naismith, Enrique Alvarez, Becky J. Parks, Nereo Bresolin, Anne H. Cross, Laura M. Piccio, Daniela Galimberti, Elio Scarpini

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.

Original languageEnglish
Pages (from-to)1938-1942
Number of pages5
JournalMultiple Sclerosis Journal
Volume19
Issue number14
DOIs
StatePublished - Dec 2013

Keywords

  • Multiple sclerosis
  • biomarkers
  • demyelination
  • microRNA
  • serum

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