Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

Chiara Fenoglio; Elisa Ridolfi; Claudia Cantoni; Milena De Riz; Rossana Bonsi; Maria Serpente; Chiara Villa; Anna M. Pietroboni; Robert T. Naismith; Enrique Alvarez; Becky J. Parks; Nereo Bresolin; Anne H. Cross; Laura M. Piccio; Daniela Galimberti; Elio Scarpini

doi:10.1177/1352458513485654

Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

Chiara Fenoglio, Elisa Ridolfi, Claudia Cantoni, Milena De Riz, Rossana Bonsi, Maria Serpente, Chiara Villa, Anna M. Pietroboni, Robert T. Naismith, Enrique Alvarez, Becky J. Parks, Nereo Bresolin, Anne H. Cross, Laura M. Piccio, Daniela Galimberti, Elio Scarpini

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103 Scopus citations

Abstract

Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.

Original language	English
Pages (from-to)	1938-1942
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	19
Issue number	14
DOIs	https://doi.org/10.1177/1352458513485654
State	Published - Dec 2013

Keywords

Multiple sclerosis
biomarkers
demyelination
microRNA
serum

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Fenoglio, C., Ridolfi, E., Cantoni, C., De Riz, M., Bonsi, R., Serpente, M., Villa, C., Pietroboni, A. M., Naismith, R. T., Alvarez, E., Parks, B. J., Bresolin, N., Cross, A. H., Piccio, L. M., Galimberti, D., & Scarpini, E. (2013). Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. Multiple Sclerosis Journal, 19(14), 1938-1942. https://doi.org/10.1177/1352458513485654

@article{07fb0fbe9528409fb921e846bfd3fabd,

title = "Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis",

abstract = "Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.",

keywords = "Multiple sclerosis, biomarkers, demyelination, microRNA, serum",

author = "Chiara Fenoglio and Elisa Ridolfi and Claudia Cantoni and {De Riz}, Milena and Rossana Bonsi and Maria Serpente and Chiara Villa and Pietroboni, {Anna M.} and Naismith, {Robert T.} and Enrique Alvarez and Parks, {Becky J.} and Nereo Bresolin and Cross, {Anne H.} and Piccio, {Laura M.} and Daniela Galimberti and Elio Scarpini",

note = "Funding Information: This work was supported by grants from the Italian Ministry of Health (Giovani Ricercatori 2007, D.lgs 502/92). This publication was made possible by Grant Number UL1 RR024992 from the National Center for Research Resources (NCRR) and National Center for nslational Sciences (NCATS), components of the US National Institutes of Health (NIH). L.P. is a Harry Weaver Neuroscience Scholar of the National Multiple Sclerosis Society (NMSS) (JF 2144A2/1) and is funded by the Fondazione Italiana Sclerosi Multipla (2009/R/33). E.A. is Sylvia Lawry Fellow from the National MS Society and Predoctoral Training Program at Washington University UL1RR024995. Funding Information: Dr. Naismith has received consulting fees and speaking honoraria from Acorda Therapeutics, Bayer Healthcare, Biogen Idec, EMD Serono, Genzyme Corporation and Teva Neurosciences. Research funding is through the NIH (K23NS052430-01A1), NMSS and Acorda Therapeutics. ",

year = "2013",

month = dec,

doi = "10.1177/1352458513485654",

language = "English",

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pages = "1938--1942",

journal = "Multiple Sclerosis Journal",

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Fenoglio, C, Ridolfi, E, Cantoni, C, De Riz, M, Bonsi, R, Serpente, M, Villa, C, Pietroboni, AM, Naismith, RT, Alvarez, E, Parks, BJ, Bresolin, N, Cross, AH, Piccio, LM, Galimberti, D & Scarpini, E 2013, 'Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis', Multiple Sclerosis Journal, vol. 19, no. 14, pp. 1938-1942. https://doi.org/10.1177/1352458513485654

TY - JOUR

T1 - Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

AU - Fenoglio, Chiara

AU - Ridolfi, Elisa

AU - Cantoni, Claudia

AU - De Riz, Milena

AU - Bonsi, Rossana

AU - Serpente, Maria

AU - Villa, Chiara

AU - Pietroboni, Anna M.

AU - Naismith, Robert T.

AU - Alvarez, Enrique

AU - Parks, Becky J.

AU - Bresolin, Nereo

AU - Cross, Anne H.

AU - Piccio, Laura M.

AU - Galimberti, Daniela

AU - Scarpini, Elio

N1 - Funding Information: This work was supported by grants from the Italian Ministry of Health (Giovani Ricercatori 2007, D.lgs 502/92). This publication was made possible by Grant Number UL1 RR024992 from the National Center for Research Resources (NCRR) and National Center for nslational Sciences (NCATS), components of the US National Institutes of Health (NIH). L.P. is a Harry Weaver Neuroscience Scholar of the National Multiple Sclerosis Society (NMSS) (JF 2144A2/1) and is funded by the Fondazione Italiana Sclerosi Multipla (2009/R/33). E.A. is Sylvia Lawry Fellow from the National MS Society and Predoctoral Training Program at Washington University UL1RR024995. Funding Information: Dr. Naismith has received consulting fees and speaking honoraria from Acorda Therapeutics, Bayer Healthcare, Biogen Idec, EMD Serono, Genzyme Corporation and Teva Neurosciences. Research funding is through the NIH (K23NS052430-01A1), NMSS and Acorda Therapeutics.

PY - 2013/12

Y1 - 2013/12

N2 - Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.

AB - Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.

KW - Multiple sclerosis

KW - biomarkers

KW - demyelination

KW - microRNA

KW - serum

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U2 - 10.1177/1352458513485654

DO - 10.1177/1352458513485654

M3 - Article

C2 - 24277735

AN - SCOPUS:84888616452

SN - 1352-4585

VL - 19

SP - 1938

EP - 1942

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 14

ER -

Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

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Keywords

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