Decreased cancer-independent life expectancy in the head and neck cancer population

Sean T. Massa; Lauren M. Cass; Nosayaba Osazuwa-Peters; Kara M. Christopher; Ronald J. Walker; Mark A. Varvares

doi:10.1002/hed.24850

Decreased cancer-independent life expectancy in the head and neck cancer population

Sean T. Massa, Lauren M. Cass, Nosayaba Osazuwa-Peters, Kara M. Christopher, Ronald J. Walker, Mark A. Varvares

Department of Otolaryngology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Aside from cancer mortality, patients with head and neck cancer have increased mortality risk. Identifying patients with the greatest loss of cancer-independent life expectancy can guide comprehensive survivorship programs. Methods: Age-based survival data from the Surveillance, Epidemiology, and End Result (SEER) database for patients with head and neck cancer were censored for mortality from the index cancer. Life expectancy and years of life lost (YLL) referenced to the general population were calculated. Cox proportional regression models produced hazard ratios (HRs). Results: Cancer-independent life expectancy for patients with head and neck cancer is 6.5 years shorter than expected. The greatest hazard and impact of other-cause mortality was associated with black race (HR 1.23; YLL 8.55), stage IV (HR 1.60; YLL 7.92), Medicaid (HR 1.55; YLL 12.9), and previous marriage (HR 1.49; YLL 11.4). Conclusion: Patients with head and neck cancer lives are foreshortened independent of their cancer diagnosis necessitating management of noncancer mortality to maximize overall survival.

Original language	English
Pages (from-to)	1845-1853
Number of pages	9
Journal	Head and Neck
Volume	39
Issue number	9
DOIs	https://doi.org/10.1002/hed.24850
State	Published - Sep 2017

Keywords

competing mortality
head and neck cancer
life expectancy
survivorship
years of life lost

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title = "Decreased cancer-independent life expectancy in the head and neck cancer population",

abstract = "Background: Aside from cancer mortality, patients with head and neck cancer have increased mortality risk. Identifying patients with the greatest loss of cancer-independent life expectancy can guide comprehensive survivorship programs. Methods: Age-based survival data from the Surveillance, Epidemiology, and End Result (SEER) database for patients with head and neck cancer were censored for mortality from the index cancer. Life expectancy and years of life lost (YLL) referenced to the general population were calculated. Cox proportional regression models produced hazard ratios (HRs). Results: Cancer-independent life expectancy for patients with head and neck cancer is 6.5 years shorter than expected. The greatest hazard and impact of other-cause mortality was associated with black race (HR 1.23; YLL 8.55), stage IV (HR 1.60; YLL 7.92), Medicaid (HR 1.55; YLL 12.9), and previous marriage (HR 1.49; YLL 11.4). Conclusion: Patients with head and neck cancer lives are foreshortened independent of their cancer diagnosis necessitating management of noncancer mortality to maximize overall survival.",

keywords = "competing mortality, head and neck cancer, life expectancy, survivorship, years of life lost",

author = "Massa, {Sean T.} and Cass, {Lauren M.} and Nosayaba Osazuwa-Peters and Christopher, {Kara M.} and Walker, {Ronald J.} and Varvares, {Mark A.}",

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year = "2017",

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doi = "10.1002/hed.24850",

language = "English",

volume = "39",

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T1 - Decreased cancer-independent life expectancy in the head and neck cancer population

AU - Massa, Sean T.

AU - Cass, Lauren M.

AU - Osazuwa-Peters, Nosayaba

AU - Christopher, Kara M.

AU - Walker, Ronald J.

AU - Varvares, Mark A.

PY - 2017/9

Y1 - 2017/9

N2 - Background: Aside from cancer mortality, patients with head and neck cancer have increased mortality risk. Identifying patients with the greatest loss of cancer-independent life expectancy can guide comprehensive survivorship programs. Methods: Age-based survival data from the Surveillance, Epidemiology, and End Result (SEER) database for patients with head and neck cancer were censored for mortality from the index cancer. Life expectancy and years of life lost (YLL) referenced to the general population were calculated. Cox proportional regression models produced hazard ratios (HRs). Results: Cancer-independent life expectancy for patients with head and neck cancer is 6.5 years shorter than expected. The greatest hazard and impact of other-cause mortality was associated with black race (HR 1.23; YLL 8.55), stage IV (HR 1.60; YLL 7.92), Medicaid (HR 1.55; YLL 12.9), and previous marriage (HR 1.49; YLL 11.4). Conclusion: Patients with head and neck cancer lives are foreshortened independent of their cancer diagnosis necessitating management of noncancer mortality to maximize overall survival.

AB - Background: Aside from cancer mortality, patients with head and neck cancer have increased mortality risk. Identifying patients with the greatest loss of cancer-independent life expectancy can guide comprehensive survivorship programs. Methods: Age-based survival data from the Surveillance, Epidemiology, and End Result (SEER) database for patients with head and neck cancer were censored for mortality from the index cancer. Life expectancy and years of life lost (YLL) referenced to the general population were calculated. Cox proportional regression models produced hazard ratios (HRs). Results: Cancer-independent life expectancy for patients with head and neck cancer is 6.5 years shorter than expected. The greatest hazard and impact of other-cause mortality was associated with black race (HR 1.23; YLL 8.55), stage IV (HR 1.60; YLL 7.92), Medicaid (HR 1.55; YLL 12.9), and previous marriage (HR 1.49; YLL 11.4). Conclusion: Patients with head and neck cancer lives are foreshortened independent of their cancer diagnosis necessitating management of noncancer mortality to maximize overall survival.

KW - competing mortality

KW - head and neck cancer

KW - life expectancy

KW - survivorship

KW - years of life lost

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SP - 1845

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JO - Head and Neck

JF - Head and Neck

IS - 9

ER -

Decreased cancer-independent life expectancy in the head and neck cancer population

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Keywords

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