Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills

Xuhua Wang, Yuanyuan Liu, Xinjian Li, Zicong Zhang, Hengfu Yang, Yu Zhang, Philip R. Williams, Noaf S.A. Alwahab, Kush Kapur, Bin Yu, Yiming Zhang, Mengying Chen, Haixia Ding, Charles R. Gerfen, Kuan Hong Wang, Zhigang He

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control across different species. However, their organizational principle remains unclear. By using a retrograde labeling system, we defined the requirement of CSNs in the execution of a skilled forelimb food-pellet retrieval task in mice. In vivo imaging of CSN activity during performance revealed the sequential activation of topographically ordered functional ensembles with moderate local mixing. Region-specific manipulations indicate that CSNs from caudal or rostral forelimb area control reaching or grasping, respectively, and both are required in the transitional pronation step. These region-specific CSNs terminate in different spinal levels and locations, therefore preferentially connecting with the premotor neurons of muscles engaged in different steps of the task. Together, our findings suggest that spatially defined groups of CSNs encode different movement modules, providing a logic for parallel-ordered corticospinal circuits to orchestrate multistep motor skills. What are the neuronal circuits underlying goal-directed motor skills, and how are they organized and spatiotemporally activated?

Original languageEnglish
Pages (from-to)440-455.e14
JournalCell
Volume171
Issue number2
DOIs
StatePublished - Oct 5 2017
Externally publishedYes

Keywords

  • corticospinal neurons
  • food-pellet retrieval task
  • goal-directed motor skills
  • in vivo imaging
  • motor cortex
  • muscle control
  • premotor neurons

Fingerprint Dive into the research topics of 'Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills'. Together they form a unique fingerprint.

  • Cite this

    Wang, X., Liu, Y., Li, X., Zhang, Z., Yang, H., Zhang, Y., Williams, P. R., Alwahab, N. S. A., Kapur, K., Yu, B., Zhang, Y., Chen, M., Ding, H., Gerfen, C. R., Wang, K. H., & He, Z. (2017). Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell, 171(2), 440-455.e14. https://doi.org/10.1016/j.cell.2017.08.014