Decompensation of cardiac hypertrophy: Cellular mechanisms and novel therapeutic targets

Research output: Contribution to journalReview articlepeer-review

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Abstract

Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.

Original languageEnglish
Pages (from-to)56-64
Number of pages9
JournalPhysiology
Volume22
Issue number1
DOIs
StatePublished - Feb 2007

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