Decline in the endocochlear potential corresponds to decreased Na,K-ATPase activity in the lateral wall of quiet-aged gerbils

M. A. Gratton; B. J. Smyth; C. F. Lam; F. A. Boettcher; R. A. Schmiedt

doi:10.1016/S0378-5955(97)00034-8

Decline in the endocochlear potential corresponds to decreased Na,K-ATPase activity in the lateral wall of quiet-aged gerbils

M. A. Gratton
, B. J. Smyth
, C. F. Lam
, F. A. Boettcher
, R. A. Schmiedt

Department of Otolaryngology

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

The ion transport-mediating enzyme, Na,K-ATPase, is abundantly present in the cochlear lateral wall. This enzyme is essential for the generation and maintenance of the endocochlear potential. Diminished enzyme activity has been observed previously in the lateral wall of quiet-aged gerbils. The present study was designed to investigate the impact of the age-related decline in Na,K-ATPase specific activity upon auditory function. Measures of the resting endocochlear potential value and the level of Na,K-ATPase specific activity were made in cochleae obtained from gerbils aged in quiet conditions. Analysis revealed a high degree of correspondence between the level of lateral wall Na,K-ATPase specific activity and the value of the endocochlear potential measured in the round window/turn 1 region of the cochlea. Nonlinear regression models showed a strong relationship between the age-related reductions in enzyme activity and the magnitude of the endocochlear potential. The data suggest that during metabolic presbyacusis a decrease in Na,K-ATPase specific activity can explain most, but not all, of the decline in the endocochlear potential.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Hearing research
Volume	108
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-5955(97)00034-8
State	Published - Jun 1997

Keywords

Aging
Cochlea
Ion transport
Prebyabyacusis
Spiral ligament
Stria vascularis

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10.1016/S0378-5955(97)00034-8

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title = "Decline in the endocochlear potential corresponds to decreased Na,K-ATPase activity in the lateral wall of quiet-aged gerbils",

abstract = "The ion transport-mediating enzyme, Na,K-ATPase, is abundantly present in the cochlear lateral wall. This enzyme is essential for the generation and maintenance of the endocochlear potential. Diminished enzyme activity has been observed previously in the lateral wall of quiet-aged gerbils. The present study was designed to investigate the impact of the age-related decline in Na,K-ATPase specific activity upon auditory function. Measures of the resting endocochlear potential value and the level of Na,K-ATPase specific activity were made in cochleae obtained from gerbils aged in quiet conditions. Analysis revealed a high degree of correspondence between the level of lateral wall Na,K-ATPase specific activity and the value of the endocochlear potential measured in the round window/turn 1 region of the cochlea. Nonlinear regression models showed a strong relationship between the age-related reductions in enzyme activity and the magnitude of the endocochlear potential. The data suggest that during metabolic presbyacusis a decrease in Na,K-ATPase specific activity can explain most, but not all, of the decline in the endocochlear potential.",

keywords = "Aging, Cochlea, Ion transport, Prebyabyacusis, Spiral ligament, Stria vascularis",

author = "Gratton, \{M. A.\} and Smyth, \{B. J.\} and Lam, \{C. F.\} and Boettcher, \{F. A.\} and Schmiedt, \{R. A.\}",

note = "Funding Information: The authors appreciate the statistical advice of Dr. Samuel Saunders. We thank Drs. Bradley Schulte and Robert Burkard as well as two anonymous reviewers for a critical reading of the manuscript. This work was supported by Research Grant P01 DC00422-08 from the National Institute of Deafness and Other Communication Disorders, National Institutes of Health. ",

year = "1997",

month = jun,

doi = "10.1016/S0378-5955(97)00034-8",

language = "English",

volume = "108",

pages = "9--16",

journal = "Hearing research",

issn = "0378-5955",

number = "1-2",

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TY - JOUR

T1 - Decline in the endocochlear potential corresponds to decreased Na,K-ATPase activity in the lateral wall of quiet-aged gerbils

AU - Gratton, M. A.

AU - Smyth, B. J.

AU - Lam, C. F.

AU - Boettcher, F. A.

AU - Schmiedt, R. A.

N1 - Funding Information: The authors appreciate the statistical advice of Dr. Samuel Saunders. We thank Drs. Bradley Schulte and Robert Burkard as well as two anonymous reviewers for a critical reading of the manuscript. This work was supported by Research Grant P01 DC00422-08 from the National Institute of Deafness and Other Communication Disorders, National Institutes of Health.

PY - 1997/6

Y1 - 1997/6

N2 - The ion transport-mediating enzyme, Na,K-ATPase, is abundantly present in the cochlear lateral wall. This enzyme is essential for the generation and maintenance of the endocochlear potential. Diminished enzyme activity has been observed previously in the lateral wall of quiet-aged gerbils. The present study was designed to investigate the impact of the age-related decline in Na,K-ATPase specific activity upon auditory function. Measures of the resting endocochlear potential value and the level of Na,K-ATPase specific activity were made in cochleae obtained from gerbils aged in quiet conditions. Analysis revealed a high degree of correspondence between the level of lateral wall Na,K-ATPase specific activity and the value of the endocochlear potential measured in the round window/turn 1 region of the cochlea. Nonlinear regression models showed a strong relationship between the age-related reductions in enzyme activity and the magnitude of the endocochlear potential. The data suggest that during metabolic presbyacusis a decrease in Na,K-ATPase specific activity can explain most, but not all, of the decline in the endocochlear potential.

AB - The ion transport-mediating enzyme, Na,K-ATPase, is abundantly present in the cochlear lateral wall. This enzyme is essential for the generation and maintenance of the endocochlear potential. Diminished enzyme activity has been observed previously in the lateral wall of quiet-aged gerbils. The present study was designed to investigate the impact of the age-related decline in Na,K-ATPase specific activity upon auditory function. Measures of the resting endocochlear potential value and the level of Na,K-ATPase specific activity were made in cochleae obtained from gerbils aged in quiet conditions. Analysis revealed a high degree of correspondence between the level of lateral wall Na,K-ATPase specific activity and the value of the endocochlear potential measured in the round window/turn 1 region of the cochlea. Nonlinear regression models showed a strong relationship between the age-related reductions in enzyme activity and the magnitude of the endocochlear potential. The data suggest that during metabolic presbyacusis a decrease in Na,K-ATPase specific activity can explain most, but not all, of the decline in the endocochlear potential.

KW - Aging

KW - Cochlea

KW - Ion transport

KW - Prebyabyacusis

KW - Spiral ligament

KW - Stria vascularis

UR - https://www.scopus.com/pages/publications/0030963031

U2 - 10.1016/S0378-5955(97)00034-8

DO - 10.1016/S0378-5955(97)00034-8

M3 - Article

C2 - 9213117

AN - SCOPUS:0030963031

SN - 0378-5955

VL - 108

SP - 9

EP - 16

JO - Hearing research

JF - Hearing research

IS - 1-2

ER -

Decline in the endocochlear potential corresponds to decreased Na,K-ATPase activity in the lateral wall of quiet-aged gerbils

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