Death begets failure in the heart

Roger S.Y. Foo, Kartik Mani, Richard N. Kitsis

Research output: Contribution to journalReview article

249 Scopus citations

Abstract

Recently, low - but abnormal - rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

Original languageEnglish
Pages (from-to)565-571
Number of pages7
JournalJournal of Clinical Investigation
Volume115
Issue number3
DOIs
StatePublished - Mar 2005
Externally publishedYes

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