Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia

Lee Sooyeon; Kristina L. Go; Jae Sung Kim

doi:10.1080/23723556.2015.1087452

Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia

Lee Sooyeon
, Kristina L. Go
, Jae Sung Kim

Research output: Contribution to journal › Comment/debate

19 Scopus citations

Abstract

Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.

Original language	English
Article number	e1087452
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1080/23723556.2015.1087452
State	Published - Mar 3 2016

Keywords

Autophagy
ischemia/reperfusion
mitochondria
mitofusin 2
sirtuin 1

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10.1080/23723556.2015.1087452

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title = "Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia",

abstract = "Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.",

keywords = "Autophagy, ischemia/reperfusion, mitochondria, mitofusin 2, sirtuin 1",

author = "Lee Sooyeon and Go, \{Kristina L.\} and Kim, \{Jae Sung\}",

note = "Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 Taylor \& Francis Group, LLC.",

year = "2016",

month = mar,

day = "3",

doi = "10.1080/23723556.2015.1087452",

language = "English",

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journal = "Molecular and Cellular Oncology",

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TY - JOUR

T1 - Deacetylation of mitofusin-2 by sirtuin-1

T2 - A critical event in cell survival after ischemia

AU - Sooyeon, Lee

AU - Go, Kristina L.

AU - Kim, Jae Sung

PY - 2016/3/3

Y1 - 2016/3/3

N2 - Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.

AB - Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.

KW - Autophagy

KW - ischemia/reperfusion

KW - mitochondria

KW - mitofusin 2

KW - sirtuin 1

UR - https://www.scopus.com/pages/publications/85006449117

U2 - 10.1080/23723556.2015.1087452

DO - 10.1080/23723556.2015.1087452

M3 - Comment/debate

C2 - 27308609

AN - SCOPUS:85006449117

SN - 2372-3556

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 2

M1 - e1087452

ER -

Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia

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Keywords

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