Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia

Lee Sooyeon, Kristina L. Go, Jae Sung Kim

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.

Original languageEnglish
Article numbere1087452
JournalMolecular and Cellular Oncology
Volume3
Issue number2
DOIs
StatePublished - Mar 3 2016

Keywords

  • Autophagy
  • ischemia/reperfusion
  • mitochondria
  • mitofusin 2
  • sirtuin 1

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