Abstract
Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.
Original language | English |
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Article number | e1087452 |
Journal | Molecular and Cellular Oncology |
Volume | 3 |
Issue number | 2 |
DOIs |
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State | Published - Mar 3 2016 |
Keywords
- Autophagy
- ischemia/reperfusion
- mitochondria
- mitofusin 2
- sirtuin 1