De-novo onset of eosinophilic esophagitis after large volume allergen exposures

W. Asher Wolf, Maya R. Jerath, Evan S. Dellon

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition believed to have an allergic component, but the timing of the initial allergen triggers that cause the disease is poorly understood. While the clinical presentation of EoE is often of longstanding symptoms, in animal models, acute exposure to an allergen challenge successfully produces EoE. In this report, we present three cases of individuals who developed esophageal eosinophilia and EoE shortly after a clearly identified exposure to aeroallergens. These cases highlight the allergic etiology of EoE, and provide a link from humans to the previously described experimental mechanisms.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalJournal of Gastrointestinal and Liver Diseases
Issue number2
StatePublished - Jun 2013


  • Allergen
  • Eosinophilic esophagitis
  • Etiology


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